ArticleGenetics2015
Potency of transgenic effectors for neurogenetic manipulation in Drosophila larvae.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Multisensory pathogen detection drives rapid escape and shapes host-microbe interactions in Drosophila larvae.PLoS pathogens · 2026Article
- Selective octopaminergic tuning of mushroom body circuits during memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors.iScience · 2025Article
- SIFa peptidergic neurons orchestrate the internal states and energy balance of male Drosophila melanogaster.PLoS biology · 2025Article
- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells.Nature communications · 2019Article
- A comprehensive anatomical map of the peripheral octopaminergic/tyraminergic system of Drosophila melanogaster.Scientific reports · 2018Article
- Functional Imaging and Optogenetics inGenetics · 2018Review
- Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues.Nature communications · 2018Article
- Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.Frontiers in neuroscience · 2018Article
- Two Pairs ofFrontiers in behavioral neuroscience · 2018Article
- A subset of interneurons required for Drosophila larval locomotion.Molecular and cellular neurosciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic manipulations of neuronal activity are a cornerstone of studies aimed to identify the functional impact of defined neurons for animal behavior. With its small nervous system, rapid life cycle, and genetic amenability, the fruit fly Drosophila melanogaster provides an attractive model system to study neuronal circuit function. In the past two decades, a large repertoire of elegant genetic tools has been developed to manipulate and study neural circuits in the fruit fly. Current techniques allow genetic ablation, constitutive silencing, or hyperactivation of neuronal activity and also include conditional thermogenetic or optogenetic activation or inhibition. As for all genetic techniques, the choice of the proper transgenic tool is essential for behavioral studies. Potency and impact of effectors may vary in distinct neuron types or distinct types of behavior. We here systematically test genetic effectors for their potency to alter the behavior of Drosophila larvae, using two distinct behavioral paradigms: general locomotor activity and directed, visually guided navigation. Our results show largely similar but not equal effects with different effector lines in both assays. Interestingly, differences in the magnitude of induced behavioral alterations between different effector lines remain largely consistent between the two behavioral assays. The observed potencies of the effector lines in aminergic and cholinergic neurons assessed here may help researchers to choose the best-suited genetic tools to dissect neuronal networks underlying the behavior of larval fruit flies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.