ArticleArteriosclerosis, thrombosis, and vascular biology2015
Association between physical activity and peripheral artery disease and carotid artery stenosis in a self-referred population of 3 million adults.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Validation of Risk Prediction Models to Detect Asymptomatic Carotid Stenosis.Journal of the American Heart Association · 2020Pooled it
- Active commuting and atherosclerosis in a population-based sample of middle-aged adults: the Swedish CArdioPulmonary bioImage study (SCAPIS).British journal of sports medicine · 2026Article
- Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Influence of a six-month home-based individualized physical activity intervention on carotid plaque instability measured by magnetic resonance imaging: a randomized controlled clinical trial.EClinicalMedicine · 2025Article
- Sex-Specific Multimorbidity-Multibehaviour Patterns in Primary Care Populations.International journal of environmental research and public health · 2025Observational
- Atherosclerosis Prevalence among Different Physical Activity Patterns in Adult Men.Journal of clinical medicine · 2024Article
- Brazilian Angiology and Vascular Surgery Society Guidelines for the treatment of extracranial cerebrovascular disease.Jornal vascular brasileiro · 2024Article
- Article
- Risks and outcomes of critical limb ischemia in hemodialysis patients: a prospective cohort study.Clinical kidney journal · 2023Article
- Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.Journal of the American Heart Association · 2022Article
- Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis.Antioxidants (Basel, Switzerland) · 2022Article
- Association of sedentary time and carotid atherosclerotic plaques in patients with type 2 diabetes.Journal of diabetes · 2022Article
- The Interaction Between Self-Reported Sleep Duration and Physical Activity on Peripheral Artery Disease in Chinese Adults: A Cross-Sectional Analysis in the Tianning Cohort Study.Risk management and healthcare policy · 2021Article
- Physical Activity in Patients with Symptomatic Peripheral Artery Disease: Insights from the PORTRAIT Registry.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2020Article
- Body mass index and peripheral artery disease.Atherosclerosis · 2020Article
- The effect of traditional Tibetan guozhuang dance on vascular health in elderly individuals living at high altitudes.American journal of translational research · 2020Article
- Physical Activity and Subsequent Risk of Hospitalization With Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study.Journal of the American Heart Association · 2019Article
- Association between physical activity and sub-types of cardiovascular disease death causes in a general population cohort.European journal of epidemiology · 2019Article
- Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity.Sports medicine (Auckland, N.Z.) · 2018Review
- Life's Simple 7 and Peripheral Artery Disease Risk: The Atherosclerosis Risk in Communities Study.American journal of preventive medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlthough the relationship between physical activity and coronary heart disease is well characterized, a paucity of data exists on physical activity and vascular disease in other arterial territories. This study examined the prevalence of peripheral artery disease (PAD) and carotid artery stenosis (CAS) in association with physical activity. APPROACH AND
resultsThe association between physical activity and vascular disease was examined in >3 million self-referred US participants in the United States from 2003 to 2008 who completed a medical and lifestyle questionnaire in the Life Line screening program. All subjects were evaluated by screening ankle brachial indices <0.90 for PAD and ultrasound imaging for CAS >50%. Multivariable logistic regression modeling was used to estimate odds of disease. Among 3 250 350 subjects, 63% of the population engaged in some leisure time vigorous physical activity. After adjustment for age, sex, race/ethnicity, hypertension, hypercholesterolemia, smoking status, diabetes mellitus, body mass index, and family history of cardiovascular disease, subjects who reported any physical activity had a significantly lower odds of PAD (odds ratio, 0.64; 95% confidence interval, 0.63-0.65) and CAS (odds ratio, 0.80; 95% confidence interval, 0.79-0.81). The association between physical activity with PAD and CAS was robust when stratified by sex, race, and age categories. Physical activity intensity frequency was associated with lower PAD and CAS in a graded manner (P trend <0.0001 for both). Findings seemed unaffected by confounding by comorbidity or indication.
conclusionsIn a large population-based study, higher levels of physical activity were independently associated with lower odds of vascular disease in the lower extremities and carotid arteries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.