ReviewVeterinary research2014
Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology.
Review in Veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Article
- Cross-species oncolytic virotherapy in vitro: BoHV4EGFPΔTK as a novel candidate against canine osteosarcoma and histiocytic sarcoma.Veterinary research communications · 2026Article
- Establishment of an Indirect ELISA for Bovine Infectious Rhinotracheitis Based on Eukaryotic Expression of gD Protein in CHO Cells.Veterinary sciences · 2026Article
- Generation, characterization, and application of caprine herpesvirus 1 secreted glycoprotein D.Microbiology spectrum · 2026Article
- Pantinin-Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization.ChemMedChem · 2025Article
- Infectious bovine rhinotracheitis: Unveiling the hidden threat to livestock productivity and global trade.Open veterinary journal · 2024Review
- Prevalence of bovine herpes virus-1 among reproductive disorders in cattle and buffaloes in Punjab region of India.Virusdisease · 2024Article
- Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen.Viruses · 2024Article
- Humoral Immune Response of Mice against a Vaccine Candidate Composed of a Chimera of gB of Bovine Alphaherpesviruses 1 and 5.Vaccines · 2023Article
- Preliminary Evaluation ofACS omega · 2023Article
- Bacillus Toyonensis BCT-7112Probiotics and antimicrobial proteins · 2021Article
- A GMMA-CPS-Based Vaccine for Non-TyphoidalVaccines · 2021Article
- Role of Sphingomyelin in Alphaherpesvirus Entry.Journal of virology · 2019Article
- Bovine Herpesvirus 1 Entry by a Low-pH Endosomal Pathway.Journal of virology · 2018Article
- Cloning and sequencingVeterinary world · 2018Article
- Antiviral Immunotoxin AgainstFrontiers in microbiology · 2018Article
- Protein Composition of the Bovine Herpesvirus 1.1 Virion.Veterinary sciences · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. Furthermore, the interactions of gD with the host immune system are discussed. Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration.
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