ArticleScientific reports2014
Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
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- TRPA1 as a OScientific reports · 2023Article
- Protective Role of Capsaicin in Neurological Disorders: An Overview.Neurochemical research · 2022Review
- Beneficial Effects of Capsaicin in Disorders of the Central Nervous System.Molecules (Basel, Switzerland) · 2022Review
- The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances.Frontiers in molecular neuroscience · 2022Review
- Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study.Journal of traditional and complementary medicine · 2021Article
- Suppressive Effects of Transient Receptor Potential Melastatin 8 Agonist on Epileptiform Discharges and Epileptic Seizures.Frontiers in pharmacology · 2021Article
- Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures.Neurochemical research · 2020Article
- Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil.The Journal of physiology · 2019Article
- Suppressive Effects of Cooling Compounds Icilin on Penicillin G-Induced Epileptiform Discharges in Anesthetized Rats.Frontiers in pharmacology · 2019Article
- Endocannabinoid-LTP Mediated by CB1 and TRPV1 Receptors Encodes for Limited Occurrences of Coincident Activity in Neocortex.Frontiers in cellular neuroscience · 2018Article
- Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.Experimental neurology · 2017Article
- Article
- Cellular and Molecular Targets of Menthol Actions.Frontiers in pharmacology · 2017Review
- Effects of menthol-flavored substances at the cellular level on oral mucosal sites.Dental research journalArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores how different AIS modulate neural response in layer 5 pyramidal neurons of S1 neocortex. The AIS tested are agonists of TRPV1/3, TRPM8 or TRPA1. Our results demonstrate that capsaicin, eugenol, menthol, icilin and cinnamaldehyde, but not AITC dampen the generation of APs in a voltage- and time-dependent manner. This effect was further tested for the TRPM8 ligands in the presence of a TRPM8 blocker (BCTC) and on TRPM8 KO mice. The observable effect was still present. Finally, the influence of the selected AIS was tested on in vitro gabazine-induced seizures. Results coincide with the above observations: except for cinnamaldehyde, the same AIS were able to reduce the number, duration of the AP bursts and increase the concentration of gabazine needed to elicit them. In conclusion, our data suggests that some of these AIS can modulate glutamatergic neurons in the brain through a TRP-independent pathway, regardless of whether the neurons are stimulated intracellularly or by hyperactive microcircuitry.
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