ArticleScientific reports2014
Determination of motility forces on isolated chromosomes with laser tweezers.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Direct measurement of absolute radiation pressure of leds in nanopascal range under ambient conditions with microcantilever.Scientific reports · 2025Article
- Laser Scissors and Tweezers to Study Chromosomes: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- Genetic Material Manipulation and Modification by Optical Trapping and Nanosurgery-A Perspective.Frontiers in bioengineering and biotechnology · 2020Review
- Single-Crystal Rutile TiOACS photonics · 2019Article
- Calibration of force detection for arbitrarily shaped particles in optical tweezers.Scientific reports · 2018Article
- Brownian motion near an elastic cell membrane: A theoretical study.The European physical journal. E, Soft matter · 2018Article
- Mitotic tethers connect sister chromosomes and transmit "cross-polar" force during anaphase A of mitosis in PtK2 cells.Biomedical optics express · 2017Article
- Optical trapping of otoliths drives vestibular behaviours in larval zebrafish.Nature communications · 2017Article
- Genomic Instability in Cancer: Teetering on the Limit of Tolerance.Cancer research · 2017Review
- Extending calibration-free force measurements to optically-trapped rod-shaped samples.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Quantitative determination of the motility forces of chromosomes during cell division is fundamental to understanding a process that is universal among eukaryotic organisms. Using an optical tweezers system, isolated mammalian chromosomes were held in a 1064 nm laser trap. The minimum force required to move a single chromosome was determined to be ≈ 0.8-5 pN. The maximum transverse trapping efficiency of the isolated chromosomes was calculated as ≈ 0.01-0.02. These results confirm theoretical force calculations of ≈ 0.1-12 pN to move a chromosome on the mitotic or meiotic spindle. The verification of these results was carried out by calibration of the optical tweezers when trapping microspheres with a diameter of 4.5-15 µm in media with 1-7 cP viscosity. The results of the chromosome and microsphere trapping experiments agree with optical models developed to simulate trapping of cylindrical and spherical specimens.
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Registered trials
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