ArticleJournal of the American Heart Association2014
Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical predictors of depression treatment outcomes in patients with coronary heart disease.Journal of psychosomatic research · 2016Trial
- Psychological Distress in Adults With Myocardial Infarction: Implications for Health Care Utilization and Expenditure.JACC. Advances · 2025Article
- Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease.Journal of the American Heart Association · 2023Article
- Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction.Journal of clinical medicine · 2022Article
- "Leaky Gut" as a Keystone of the Connection between Depression and Obstructive Sleep Apnea Syndrome? A Rationale and Study Design.Metabolites · 2022Article
- Spiritual Well-Being and Its Association with Coronary Artery Disease.Journal of religion and health · 2022Article
- Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation.European heart journal · 2020Article
- Effects of a mental stress challenge on brain function in coronary artery disease patients with and without depression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- The Relation of Psychosocial Distress With Myocardial Perfusion and Stress-Induced Myocardial Ischemia.Psychosomatic medicine · 2019Article
- Coronary Artery Spasm, Coronary Reactivity, and Their Psychological Context.Psychosomatic medicine · 2019Article
- Pain-induced peripheral artery tonometry scores in the control arm are impaired in patients with apical ballooning syndrome.Medicine · 2019Article
- The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The Mental Stress Ischemia Prognosis Study: Objectives, Study Design, and Prevalence of Inducible Ischemia.Psychosomatic medicine · 2017Article
- Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women.Neuroscience and biobehavioral reviews · 2017Review
- Sex Differences in Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Heart Disease.Journal of the American Heart Association · 2016Article
- Increased prevalence of anxiety and depression symptoms in patients with coronary artery disease before and after percutaneous coronary intervention treatment.BMC psychiatry · 2016Article
- Impact of Prostate Cancer Diagnosis on Noncancer Hospitalizations Among Elderly Medicare Beneficiaries With Incident Prostate Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2016Article
- Emotional triggering of cardiac dysfunction: the present and future.Current cardiology reports · 2015Review
- Positive emotion and cardiovascular disease in elderly people.International journal of clinical and experimental medicine · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDepression is prevalent in coronary heart disease (CHD) patients and increases risk for acute coronary syndrome (ACS) recurrence and mortality despite optimal medical care. The pathways underlying this risk remain elusive. Psychological stress (PS) can provoke impairment in myocardial perfusion and trigger ACS. A confluence of acute PS with depression might reveal coronary vascular mechanisms of risk. We tested whether depression increased risk for impaired myocardial perfusion during acute PS among patients with stable CHD. METHODS AND
resultsPatients (N=146) completed the Beck Depression Inventory-I (BDI-I), a measure of depression linked to recurrent ACS and post-ACS mortality, and underwent single-photon emission computed tomography myocardial perfusion imaging at rest and during acute PS. The likelihood of new/worsening impairment in myocardial perfusion from baseline to PS as a function of depression severity was tested. On the BDI-I, 41 patients scored in the normal range, 48 in the high normal range, and 57 in the depressed range previously linked to CHD prognosis. A BDI-I score in the depressed range was associated with a significantly greater likelihood of new/worsening impairment in myocardial perfusion from baseline to PS (odds ratio =2.89, 95% CI: 1.26 to 6.63, P=0.012). This remained significant in models controlling ACS recurrence/mortality risk factors and medications. There was no effect for selective serotonin reuptake inhibitor medications.
conclusionsDepressed patients with CHD are particularly susceptible to impairment in myocardial perfusion during PS. The confluence of PS with depression may contribute to a better understanding of the depression-associated risk for ACS recurrence and mortality.
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