Evidence map›Paper›PMID 25359352›Full record

ArticleThe European respiratory journal2015

Smoking adversely affects treatment response, outcome and relapse in tuberculosis.

Chi C Leung, Wing W Yew, Chi K Chan, Kwok C Chang, Wing S Law, Shuk N Lee, Lai B Tai, Eric C C Leung, Ronald K F Au, Shan S Huang and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 185 citations in OpenAlex.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chi C LeungTB and Chest Service, Dept of Health, Hong Kong, China.
Wing W YewStanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.
Chi K ChanTB and Chest Service, Dept of Health, Hong Kong, China.
Kwok C ChangTB and Chest Service, Dept of Health, Hong Kong, China.
Wing S LawTB and Chest Service, Dept of Health, Hong Kong, China.
Shuk N LeeTB and Chest Service, Dept of Health, Hong Kong, China.
Lai B TaiTB and Chest Service, Dept of Health, Hong Kong, China.
Eric C C LeungTB and Chest Service, Dept of Health, Hong Kong, China.
Ronald K F AuTB and Chest Service, Dept of Health, Hong Kong, China.
Shan S HuangTB and Chest Service, Dept of Health, Hong Kong, China.
Cheuk M TamTB and Chest Service, Dept of Health, Hong Kong, China.
Department of Health · CNChinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of smoking on tuberculosis outcome was evaluated in a territory-wide treatment programme. 16,345 consecutive patients undergoing chemotherapy for active tuberculosis in government chest clinics in Hong Kong from 2001 to 2003 were followed up prospectively for 2 years for treatment outcome and subsequently tracked through the territory-wide tuberculosis notification registry for relapse until the end of 2012. Smoking was associated with more extensive lung disease, lung cavitation and positive sputum smear and culture at the baseline. In both current smokers and ex-smokers, sputum smears and cultures were significantly more likely to remain positive after 2 months of treatment. Both categories of smokers were significantly less likely to achieve cure or treatment completion within 2 years. Overall, 16.7% of unsuccessful treatment outcomes were attributable to smoking, with the key contributor being default in current smokers and death in ex-smokers. Among successful treatment completers, there was a clear gradient (hazard ratios of 1.00, 1.33 and 1.63) of relapse risk from never-smokers to ex-smokers and current smokers, with an overall population attributable risk of 19.4% (current smokers: 12.2%; ex-smokers: 7.2%). Smoking adversely affects baseline disease severity, bacteriological response, treatment outcome and relapse in tuberculosis. Smoking cessation likely reduces relapse and secondary transmission.

Indexed as

Mycobacterium tuberculosisSmokingTuberculosis, PulmonaryAdultAgedAntitubercular AgentsFemaleFollow-Up StudiesHong KongHumansIncidenceMaleMiddle AgedRecurrenceRegistriesRisk FactorsAntitubercular Agents

Identifiers

PMID25359352
OpenAlexW2113929451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.