ArticleGenetics, selection, evolution : GSE2014
Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.
Article in Genetics, selection, evolution : GSE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Unravelling novel and pleiotropic genes for cannon bone circumference and bone mineral density in Yorkshire pigs.Journal of animal science · 2024Pooled it
- In Vivo Ultrasonographic Assessment of Bone Mineral Density and Its Impact on Semen Quality in Boars.Animals : an open access journal from MDPI · 2025Article
- Genetic analysis of protein efficiency and its association with performance and meat quality traits under a protein-restricted diet.Genetics, selection, evolution : GSE · 2023Article
- Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed.Communications biology · 2022Article
- A combined GWAS approach reveals key loci for socially-affected traits in Yorkshire pigs.Communications biology · 2021Article
- Comparative Analyses of Sperm DNA Methylomes Among Three Commercial Pig Breeds Reveal Vital Hypomethylated Regions Associated With Spermatogenesis and Embryonic Development.Frontiers in genetics · 2021Article
- Phenotyping of the Visceral Adipose Tissue Using Dual Energy X-Ray Absorptiometry (DXA) and Magnetic Resonance Imaging (MRI) in Pigs.Animals : an open access journal from MDPI · 2020Article
- Characterization of the poll allele in Brahman cattle using long-read Oxford Nanopore sequencing.Journal of animal science · 2020Article
- Identification of novel variants and candidate genes associated with porcine bone mineral density using genome-wide association study.Journal of animal science · 2020Article
- A Genome-Wide Association Study on Feed Efficiency Related Traits in Landrace Pigs.Frontiers in genetics · 2020Article
- "Sex" and body region effects on bone mineralization in male pigs.Archives animal breeding · 2020Article
- Mapping genomic regions affecting milk traits in Sarda sheep by using the OvineSNP50 Beadchip and principal components to perform combined linkage and linkage disequilibrium analysis.Genetics, selection, evolution : GSE · 2019Article
- Integrating genome-wide co-association and gene expression to identify putative regulators and predictors of feed efficiency in pigs.Genetics, selection, evolution : GSE · 2019Article
- Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation.Genetics, selection, evolution : GSE · 2018Article
- Fat deposition deficiency is critical for the high mortality of pre-weanling newborn piglets.Journal of animal science and biotechnology · 2018Article
- A systematic survey to identify lethal recessive variation in highly managed pig populations.BMC genomics · 2017Article
- Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins.The Journal of clinical endocrinology and metabolism · 2016Article
- Production of hornless dairy cattle from genome-edited cell lines.Nature biotechnology · 2016Article
- Genome-wide association and identification of candidate genes for age at puberty in swine.BMC genetics · 2016Article
- Non-invasive methods for the determination of body and carcass composition in livestock: dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging and ultrasound: invited review.Animal : an international journal of animal bioscience · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the pig is one of the most important livestock animals worldwide, mapping loci that are associated with economically important traits and/or traits that influence animal welfare is extremely relevant for efficient future pig breeding. Therefore, the purpose of this study was a genome-wide mapping of quantitative trait loci (QTL) associated with nine body composition and bone mineral traits: absolute (Fat, Lean) and percentage (FatPC, LeanPC) fat and lean mass, live weight (Weight), soft tissue X-ray attenuation coefficient (R), absolute (BMC) and percentage (BMCPC) bone mineral content and bone mineral density (BMD).
methodsData on the nine traits investigated were obtained by Dual-energy X-ray absorptiometry for 551 pigs that were between 160 and 200 days old. In addition, all pigs were genotyped using Illumina's PorcineSNP60 Genotyping BeadChip. Based on these data, a genome-wide combined linkage and linkage disequilibrium analysis was conducted. Thus, we used 44 611 sliding windows that each consisted of 20 adjacent single nucleotide polymorphisms (SNPs). For the middle of each sliding window a variance component analysis was carried out using ASReml. The underlying mixed linear model included random QTL and polygenic effects, with fixed effects of sex, housing, season and age.
resultsUsing a Bonferroni-corrected genome-wide significance threshold of P < 0.001, significant peaks were identified for all traits except BMCPC. Overall, we identified 72 QTL on 16 chromosomes, of which 24 were significantly associated with one trait only and the remaining with more than one trait. For example, a QTL on chromosome 2 included the highest peak across the genome for four traits (Fat, FatPC, LeanPC and R). The nearby gene, ZNF608, is known to be associated with body mass index in humans and involved in starvation in Drosophila, which makes it an extremely good candidate gene for this QTL.
conclusionsOur QTL mapping approach identified 72 QTL, some of which confirmed results of previous studies in pigs. However, we also detected significant associations that have not been published before and were able to identify a number of new and promising candidate genes, such as ZNF608.
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