Evidence map›Paper›PMID 25358723›Full record

Trial reportHealth and quality of life outcomes2014

Impact of a pharmaceutical care programme on health-related quality of life among women with epilepsy: a randomised controlled trial (IPHIWWE study).

Martha Losada-Camacho, Mario F Guerrero-Pabon, Pilar Garcia-Delgado, Fernando Martínez-Martinez

Abstract readPragmatic Clinical TrialRandomized Controlled Trial
In one paragraph

Trial report in Health and quality of life outcomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pharmacist services for non-hospitalised patients.The Cochrane database of systematic reviews · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martha Losada-Camacho
Mario F Guerrero-Pabon
Pilar Garcia-Delgado
Fernando Martínez-Martinez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpilepsy is a complex chronic disorder which affects health-related quality of life (HRQOL), especially in women.

methodsThis study is a pragmatic randomised controlled trial involving women with epilepsy (WWE) over 18 years of age.

resultsOne hundred eighty-two WWE entered the study and 144 (79.1%) completed it. The t-test for comparing the final QOLIE-31 scores between groups yielded a t = -2.166 and confidence interval (CI) (95%): -10.125; -0.4625, p-value =0.0319. The change (Δ) in the QOLIE-31 score for the IG was 12.45 points (p-value <0.001) and for the control group it was 2.61 (p-value =0.072). With 10.7 as the minimally important change we found a relative risk of 2.17 (CI: 1.37; 3.43) and a number needed to treat (NNT) of 3.5.

conclusionsThe study demonstrated that the application of a pharmaceutical care programme significantly improves HRQOL in WWE. The NNT we found allows a recommendation to implement the PC programme for the additional benefit that would be obtained in patients' HRQOL.

trial registrationCurrent Controlled Trials ISRCTN46864306 IPHIWWE study.

Indexed as

Health StatusPharmaceutical ServicesQuality of LifeAdolescentAdultAgedAnticonvulsantsEpilepsyFemaleHumansMiddle AgedPatient Education as TopicPatient Outcome AssessmentRiskTreatment OutcomeYoung AdultAnticonvulsants

Identifiers

PMID25358723
PMCPMC4236797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.