ArticleParticle and fibre toxicology2014
Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.
Article in Particle and fibre toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- A systematic review of environmentally persistent free radical (EPFR) formation, characteristics, and health effects: are there sufficient data for risk assessment?Journal of toxicology and environmental health. Part B, Critical reviews · 2026Pooled it
- Particulate matter air pollution: effects on the respiratory system.The Journal of clinical investigation · 2025Review
- Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.Nature communications · 2024Article
- Exploring the Relationship between Acute Coronary Syndrome, Lower Respiratory Tract Infections, and Atmospheric Pollution.Journal of clinical medicine · 2024Article
- The Effect of α-FeToxics · 2024Article
- Inhalation of particulate matter containing environmentally persistent free radicals induces endothelial dysfunction mediated via AhR activation at the air-blood interface.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Role of Electronegativity in Environmentally Persistent Free Radicals (EPFRs) Formation on ZnO.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Biochar-Derived Persistent Free Radicals: A Plethora of Environmental Applications in a Light and Shadows Scenario.Toxics · 2024Review
- Investigating environmentally persistent free radicals (EPFRs) emissions of 3D printing process.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2024Article
- Article
- Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs.Science advances · 2023Article
- Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Substantial changes in Gaseous pollutants and health effects during COVID-19 in Delhi, India.PeerJ · 2023Article
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Air Pollution-Related Respiratory Diseases and Associated Environmental Factors in Chiang Mai, Thailand, in 2011-2020.Tropical medicine and infectious disease · 2022Article
- Article
- Recent Insights into Particulate Matter (PMInternational journal of environmental research and public health · 2022Review
- Transmission of COVID-19 pandemic (Turkey) associated with short-term exposure of air quality and climatological parameters.Environmental science and pollution research international · 2022Article
- PM2.5-Related Neonatal Infections: A Global Burden Study from 1990 to 2019.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundExposures to elevated levels of particulate matter (PM) enhance severity of influenza virus infection in infants. The biological mechanism responsible for this phenomenon is unknown. The recent identification of environmentally persistent free radicals (EPFRs) associated with PM from a variety of combustion sources suggests its role in the enhancement of influenza disease severity.
methodsNeonatal mice (< seven days of age) were exposed to DCB230 (combustion derived PM with a chemisorbed EPFR), DCB50 (non-EPFR PM sample), or air for 30 minutes/day for seven consecutive days. Four days post-exposure, neonates were infected with influenza intranasally at 1.25 TCID50/neonate. Neonates were assessed for morbidity (% weight gain, peak pulmonary viral load, and viral clearance) and percent survival. Lungs were isolated and assessed for oxidative stress (8-isoprostanes and glutathione levels), adaptive immune response to influenza, and regulatory T cells (Tregs). The role of the EPFR was also assessed by use of transgenic mice expressing human superoxide dismutase 2.
resultsNeonates exposed to EPFRs had significantly enhanced morbidity and decreased survival following influenza infection. Increased oxidative stress was also observed in EPFR exposed neonates. This correlated with increased pulmonary Tregs and dampened protective T cell responses to influenza infection. Reduction of EPFR-induced oxidative stress attenuated these effects.
conclusionsNeonatal exposure to EPFR containing PM resulted in pulmonary oxidative stress and enhanced influenza disease severity. EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.
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Registered trials
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