ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2014
The circadian pattern of cardiac autonomic modulation and obesity in adolescents.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Comparison of high-intensity interval training and moderate-intensity continuous training on cardiopulmonary function, cardiac autonomic function and vascular function in adolescent boys with obesity: A randomized controlled trial.European journal of sport science · 2024Trial
- Interpreting heart rate variability in clinical context: a framework for understanding a multidimensional autonomic biomarker.Frontiers in cardiovascular medicine · 2026Review
- Heart-focused breathing technique and attitude breathing technique effects on heart rate variability in young healthy subjects.Physiological reports · 2025Article
- Article
- Influence of Chronotype and Theobromine on the 24-h Variation in Peak Expiratory Flow Rate in Healthy Adults.Journal of circadian rhythms · 2025Article
- Adiposity and cardiac autonomic function in children with a family history of obesity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Observational
- Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens.Animals : an open access journal from MDPI · 2024Article
- Standard Heart Rate Variability Parameters-Their Within-Session Stability, Reliability, and Sample Size Required to Detect the Minimal Clinically Important Effect.Journal of clinical medicine · 2023Article
- Heart Rate Asymmetry, Its Compensation, and Heart Rate Variability in Healthy Adults during 48-h Holter ECG Recordings.Journal of clinical medicine · 2023Article
- Correlation of Circadian Rhythms of Heart Rate Variability Indices with Stress, Mood, and Sleep Status in Female Medical Workers with Night Shifts.Nature and science of sleep · 2022Article
- Circadian Mechanisms: Cardiac Ion Channel Remodeling and Arrhythmias.Frontiers in physiology · 2020Review
- Presence of age- and sex-related differences in heart rate variability despite the maintenance of a suitable level of accelerometer-based physical activity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Sex- and Age-Dependent Differences in Autonomic Nervous System Functioning in Adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- Renal denervation attenuates hypertension but not salt sensitivity in ETAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Time-restricted feeding for prevention and treatment of cardiometabolic disorders.The Journal of physiology · 2017Review
- A Meta-Analysis on Sex Differences in Resting-State Vagal Activity in Children and Adolescents.Frontiers in physiology · 2017Review
- Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight.Pediatric research · 2017Article
- Office orthostatic blood pressure measurements and ambulatory blood pressure monitoring in the prediction of autonomic dysfunction.Clinical hypertension · 2017Article
- Impact of Diabetes Type 1 in Children on Autonomic Modulation at Rest and in Response to the Active Orthostatic Test.PloS one · 2016Article
- "Broken" autonomic cardiac circadian clock in obese adolescents: evidence and implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
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8 authors.
Funding
Abstract
purposeTo assess the impact of obesity and population attributes on the circadian pattern of cardiac autonomic modulation (CAM) in a population-based sample of adolescents.
methodsWe used data from 421 adolescents who completed the follow-up exam in the Penn State Children Cohort study. CAM was assessed by heart rate variability (HRV) analysis of beat-to-beat, normal R-R intervals from a 24-hour ECG, on a 30-minute basis. The HRV indices included frequency-domain (HF, LF, and LF/HF ratio) and time-domain (SDNN, RMSSD, and HR) variables. Nonlinear mixed-effect models were used to calculate a cosine periodic curve, each having three parameters quantifying its circadian period: M (mean levels of the HRV variables), Â (amplitude of the oscillation), and θ (the time of the highest oscillation).
resultsThe mean (SD) age was 16.9 (2.2) years, with 54 % male and 77 % white. The mean BMI percentile was 66, with 16 % obese (BMI percentile ≥ 95). Overall, HF (a marker of parasympathetic modulation) gradually increased from the late afternoon, reached peak amplitude around 3 a.m., and then decreased throughout the daytime until late afternoon. In contrast, obesity had adverse effects on all circadian parameters. The age, sex and race showed varying differences on the CAM circadian parameters. The adjusted means (95 %Cls) of M, Â, and θ for HF were 5.99 (5.79-6.19), 0.77 (0.66-0.89), 3:15 (2:15-4:15) a.m., and 6.21 (6.13-6.29), 0.66 (0.61-0.70), 2:45 (2:30-3:15) a.m. for obese and non-obese subjects, respectively.
conclusionThe circadian pattern of CAM can be quantified by the three cosine parameters. Obesity is associated with lower HRV even in young individuals like children/adolescents.
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