ArticleAsian-Australasian journal of animal sciences2014
Polymorphism, genetic effect and association with egg production traits of chicken matrix metalloproteinases 9 promoter.
Article in Asian-Australasian journal of animal sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 9 citations in OpenAlex.
- Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular mechanisms underlying clutch length differences in goose ovaries.Poultry science · 2026Article
- miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β-catenin signaling pathway by targeting catenin beta-1.Animal bioscience · 2021Article
- The optimization of fermentation conditions for producing cellulase ofRoyal Society open science · 2017Article
- Characterization of Chicken MMP13 Expression and Genetic Effect on Egg Production Traits of Its Promoter Polymorphisms.G3 (Bethesda, Md.) · 2016Article
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2 authors at 1 institution in 1 country.
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Abstract
Matrix metalloproteinases (MMP) are key enzymes involved in cell and tissue remodeling during ovarian follicle development and ovulation. The control of MMP9 transcription in ovarian follicles occurs through a core promoter region (-2,400 to -1,700 bp). The aim of this study was to screen genetic variations in the core promoter region and examine MMP9 transcription regulation and reproduction performance. A single cytosine deletion/insertion polymorphism was found at -1954 C(+)/C(-). Genetic association analysis indicated significant correlation between the deletion genotype (C(-)) with total egg numbers at 28 weeks (p = 0.031). Furthermore, luciferase-reporter assay showed the deletion genotype (C(-)) had significantly lower promoter activity than the insertion genotype (C(+)) in primary granulosa cells (p<0.01). Therefore, the identified polymorphism could be used for marker-assisted selection to improve chicken laying performance.
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