ReviewEpidemiology and infection2015
Syphilis: antibiotic treatment and resistance.
Review in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Neurosyphilis-Induced Psychosis in Europe: A Systematic Review of Case Reports.Pathogens (Basel, Switzerland) · 2024Pooled it
- Antibiotic treatment for newborns with congenital syphilis.The Cochrane database of systematic reviews · 2019Pooled it
- Review
- Evaluation of Artificial Intelligence-Generated DNA Aptamers Against Treponema pallidum Surface Proteins.Journal of fluorescence · 2026Article
- Penicillin Allergy Labels and High-risk Antibiotic Prescribing Among Incarcerated Individuals Receiving Antibiotics Across Four US Carceral Systems.Open forum infectious diseases · 2026Article
- Article
- Effects of TUS-NMES Combined with Glucocorticoid on Clinical Outcomes and Rehabilitation Efficacy of Neurosyphilis Patients with Cerebral Infarction.Therapeutics and clinical risk management · 2026Article
- Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesis.Communications medicine · 2025Article
- Review
- Abnormal Neurologic and Motor Function in Newborns Treated for Congenital Syphilis.Infectious disease reports · 2025Article
- Persistent syphilitic ocular manifestations despite treatment: a case series.Journal of ophthalmic inflammation and infection · 2024Article
- Oral syphilis - the great imitator: a series of six cases.British dental journal · 2024Article
- Associations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Ocular findings in neurosyphilis: a retrospective study from 2012 to 2022.Frontiers in neurology · 2024Article
- Article
- Challenges and Solutions to STI Control in the Era of HIV and STI Prophylaxis.Current HIV/AIDS reports · 2023Review
- Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019.Scientific reports · 2023Article
- Global, regional, and national trends of syphilis from 1990 to 2019: the 2019 global burden of disease study.BMC public health · 2023Article
- Immunization with Tp0954, an adhesin ofFrontiers in immunology · 2023Article
- Pathogen transmission modes determine contact network structure, altering other pathogen characteristics.Proceedings. Biological sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis is a chronic, multi-stage infectious disease that is usually transmitted sexually by contact with an active lesion of a partner or congenitally from an infected pregnant woman to her fetus. Although syphilis is still endemic in many developing countries, it has re-emerged in several developed countries. The resurgence of syphilis is a major concern to global public health, particularly since the lesions of early syphilis increase the risk of acquisition and transmission of infection with human immunodeficiency virus (HIV). Because there is no vaccine to prevent syphilis, control is mainly dependent on the identification and treatment of infected individuals and their contacts with penicillin G, the first-line drug for all stages of syphilis. The emergence of clinically significant azithromycin resistance in Treponema pallidum subsp. pallidum, the syphilis agent, has resulted in treatment failures, thus precluding the routine use of this second-line drug. Information is presented here on the diagnosis and recommended antibiotic treatment of syphilis and the challenge of macrolide-resistant T. pallidum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.