ArticleeLife2014
Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility.Nature communications · 2026Article
- Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026Article
- Oral administration of aripiprazole to Drosophila causes intestinal toxicity.Disease models & mechanisms · 2025Article
- Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023Review
- Article
- Dscam1 overexpression impairs the function of the gut nervous system in Drosophila.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior.International journal of molecular sciences · 2022Review
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
- FMRF-related peptides in Aedes aegypti midgut: neuromuscular connections and enteric nervous system.Cell and tissue research · 2021Article
- Article
- Article
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor.Neuron · 2020Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- The touchy business of gastrointestinal (GI) mechanosensitivity.Brain research · 2018Review
- TheDevelopment (Cambridge, England) · 2018Article
- Highlights for the 6th International Ion Channel Conference: ion channel structure, function, disease and therapeutics.Acta pharmaceutica Sinica. B · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Defecation allows the body to eliminate waste, an essential step in food processing for animal survival. In contrast to the extensive studies of feeding, its obligate counterpart, defecation, has received much less attention until recently. In this study, we report our characterizations of the defecation behavior of Drosophila larvae and its neural basis. Drosophila larvae display defecation cycles of stereotypic frequency, involving sequential contraction of hindgut and anal sphincter. The defecation behavior requires two groups of motor neurons that innervate hindgut and anal sphincter, respectively, and can excite gut muscles directly. These two groups of motor neurons fire sequentially with the same periodicity as the defecation behavior, as revealed by in vivo Ca(2+) imaging. Moreover, we identified a single mechanosensitive sensory neuron that innervates the anal slit and senses the opening of the intestine terminus. This anus sensory neuron relies on the TRP channel NOMPC but not on INACTIVE, NANCHUNG, or PIEZO for mechanotransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.