ArticlePloS one2014
Comparative endothelial cell response on topographically patterned titanium and silicon substrates with micrometer to sub-micrometer feature sizes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Micropatterning transcriptionally and phenotypically reprograms endothelial cells.Acta biomaterialia · 2026Article
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- Combined Porous-Monolithic TiNi Materials Surface-Modified with Electron Beam for New-Generation Rib Endoprostheses.Journal of functional biomaterials · 2023Article
- Characterizing and Engineering Biomimetic Materials for Viscoelastic Mechanotransduction Studies.Tissue engineering. Part B, Reviews · 2022Review
- Surface engineering and the application of laser-based processes to stents - A review of the latest development.Bioactive materials · 2022Review
- Hemocompatibility of micropatterned biomaterial surfaces is dependent on topographical feature size.Frontiers in physiology · 2022Article
- Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells.Frontiers in cardiovascular medicine · 2022Article
- Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology.Communications biology · 2021Review
- The Effects of Topographic Micropatterning on Endothelial Colony-Forming Cells.Tissue engineering. Part A · 2021Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Effect of Ethylene Oxide Sterilization on Polyvinyl Alcohol Hydrogel Compared with Gamma Radiation.Tissue engineering. Part A · 2020Article
- High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent.Scientific reports · 2019Article
- Surface patterning of a novel PEG-functionalized poly-l-lactide polymer to improve its biocompatibility: Applications to bioresorbable vascular stents.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Functional differences between healthy and diabetic endothelial cells on topographical cues.Biomaterials · 2018Article
- Laser Surface Microstructuring of Biocompatible Materials Using a Microlens Array and the Talbot Effect: Evaluation of the Cell Adhesion.Materials (Basel, Switzerland) · 2017Article
- Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications.Scientific reports · 2017Article
- Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.Advanced functional materials · 2017Article
- Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection.Journal of functional biomaterials · 2016Article
- Substrate Topography Guides Pore Morphology Evolution in Nanoporous Gold Thin Films.Scripta materialia · 2016Article
- Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype.ACS applied materials & interfaces · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we evaluate the in vitro response of endothelial cells (EC) to variation in precisely-defined, micrometer to sub-micrometer scale topography on two different substrate materials, titanium (Ti) and silicon (Si). Both substrates possess identically-patterned surfaces composed of microfabricated, groove-based gratings with groove widths ranging from 0.5 to 50 µm, grating pitch twice the groove width, and groove depth of 1.3 µm. These specific materials are chosen due to their relevance for implantable microdevice applications, while grating-based patterns are chosen for the potential they afford for inducing elongated and aligned cellular morphologies reminiscent of the native endothelium. Using EA926 cells, a human EC variant, we show significant improvement in cellular adhesion, proliferation, morphology, and function with decreasing feature size on patterned Ti substrates. Moreover, we show similar trending on patterned Si substrates, albeit to a lesser extent than on comparably patterned Ti substrates. Collectively, these results suggest promise for sub-micrometer topographic patterning in general, and sub-micrometer patterning of Ti specifically, as a means for enhancing endothelialization and neovascularisation for novel implantable microdevice applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.