ArticlePLoS pathogens2014
Densovirus is a mutualistic symbiont of a global crop pest (Helicoverpa armigera) and protects against a baculovirus and Bt biopesticide.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 104 citations in OpenAlex.
- Stranger swings: Temperature-dependent upsides and downsides of a densovirus in Aedes albopictus.PLoS neglected tropical diseases · 2026Article
- Baculoviruses hijack host midgut-derived tachykinin to regulate phototactic climbing behavior and promote viral transmission.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microbial Symbiosis in Lepidoptera: Analyzing the Gut Microbiota for Sustainable Pest Management.Biology · 2025Review
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- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- Discovery and characterization of novel DNA viruses inmSystems · 2024Article
- Characterization of Iflavirus in the Red Flour Beetle,Insects · 2023Article
- Variation ofFrontiers in microbiology · 2023Article
- Diversity of RNA viruses in agricultural insects.Computational and structural biotechnology journal · 2023Review
- Genomic Characterization of Endosymbiotic Bacteria Associated WithBioinformatics and biology insights · 2023Article
- Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection.Frontiers in immunology · 2022Article
- Exploring bycatch diversity of organisms in whole genome sequencing of Erebidae moths (Lepidoptera).Scientific reports · 2021Article
- Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China.eLife · 2021Article
- Prevalence of a Novel Bunyavirus in Tea Tussock Moth Euproctis pseudoconspersa (Lepidoptera: Lymantriidae).Journal of insect science (Online) · 2021Article
- The NovelFrontiers in microbiology · 2021Article
- Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.Frontiers in cellular and infection microbiology · 2021Review
- Sequencing and phylogenetic characterization of a novel Polerovirus from Nicotiana tabacum.Virus genes · 2020Article
- Article
- The Effect of Phenoloxidase Activity on Survival Is Host Plant Dependent in Virus-Infected Caterpillars.Journal of insect science (Online) · 2020Article
- Novel partiti-like viruses are conditional mutualistic symbionts in their normal lepidopteran host, African armyworm, but parasitic in a novel host, Fall armyworm.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutualistic associations between symbiotic bacteria and their hosts are common within insect systems. However, viruses are often considered as pathogens even though some have been reported to be beneficial to their hosts. Herein, we report a novel densovirus, Helicoverpa armigera densovirus-1 (HaDNV-1) that appears to be beneficial to its host. HaDNV-1 was found to be widespread in wild populations of H. armigera adults (>67% prevalence between 2008 and 2012). In wild larval populations, there was a clear negative interaction between HaDNV-1 and H. armigera nucleopolyhedrovirus (HaNPV), a baculovirus that is widely used as a biopesticide. Laboratory bioassays revealed that larvae hosting HaDNV-1 had significantly enhanced resistance to HaNPV (and lower viral loads), and that resistance to Bacillus thuringiensis (Bt) toxin was also higher at low doses. Laboratory assays indicated that the virus was mainly distributed in the fat body, and could be both horizontally- and vertically-transmitted, though the former occurred only at large challenge doses. Densovirus-positive individuals developed more quickly and had higher fecundity than uninfected insects. We found no evidence for a negative effect of HaDNV-1 infection on H. armigera fitness-related traits, strongly suggesting a mutualistic interaction between the cotton bollworm and its densovirus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.