ReviewArchives of pathology & laboratory medicine2014
Diagnostic approach to eosinophilic renal neoplasms.
Review in Archives of pathology & laboratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 120 citations in OpenAlex.
- Papillary renal cell carcinoma, formerly known as Type 2: a single institutional study addressing histologic and molecular features.Histopathology · 2026Article
- Integrated clinicopathological, genomic, and immunophenotypic landscape of renal tubulocystic oncocytoma.Frontiers in immunology · 2026Article
- Review
- Incidental renal mass in a young adult: diagnosis, robotic-assisted treatment and immunohistochemical evaluation - a case report.International journal of surgery case reports · 2025Article
- Article
- Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT.Virchows Archiv : an international journal of pathology · 2023Review
- Metastatic Clear Cell Renal Cell Carcinoma Involving the Thyroid Gland: A Clinicopathologic Study of 17 Patients.International journal of surgical pathology · 2022Review
- Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Oncocytic renal neoplasms with diffuse keratin 7 immunohistochemistry harbor frequent alterations in the mammalian target of rapamycin pathway.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer.International journal of molecular sciences · 2022Review
- Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report.Turk patoloji dergisi · 2022Article
- Expression of transient receptor potential melastatin 4 in differential diagnosis of eosinophilic renal tumors.Molecular and clinical oncology · 2021Article
- Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms.BMC medicine · 2021Article
- Quantitative image features from radiomic biopsy differentiate oncocytoma from chromophobe renal cell carcinoma.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- KRT7 Overexpression is Associated with Poor Prognosis and Immune Cell Infiltration in Patients with Pancreatic Adenocarcinoma.International journal of general medicine · 2021Article
- Features of increased malignancy in eosinophilic clear cell renal cell carcinoma.The Journal of pathology · 2020Article
- Recurrent KRAS mutations identified in papillary renal neoplasm with reverse polarity-a comparative study with papillary renal cell carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- The Labyrinth of Renal Cell Carcinoma.Cancers · 2020Article
- MiT family translocation renal cell carcinomas: A 15th anniversary update.Histology and histopathology · 2020Review
- Development of a DNA Methylation-Based Diagnostic Signature to Distinguish Benign Oncocytoma From Renal Cell Carcinoma.JCO precision oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
contextEosinophilic renal neoplasms include a spectrum of solid and papillary tumors ranging from indolent benign oncocytoma to highly aggressive malignancies. Recognition of the correct nature of the tumor, especially in biopsy specimens, is paramount for patient management.
objectiveTo review the diagnostic approach to eosinophilic renal neoplasms with light microscopy and ancillary techniques. DATA SOURCES: Review of the published literature and personal experience.
conclusionsThe following tumors are in the differential diagnosis of oncocytic renal cell neoplasm: oncocytoma, chromophobe renal cell carcinoma (RCC), hybrid tumor, tubulocystic carcinoma, papillary RCC, clear cell RCC with predominant eosinophilic cell morphology, follicular thyroid-like RCC, hereditary leiomyomatosis-associated RCC, acquired cystic disease-associated RCC, rhabdoid RCC, microphthalmia transcription factor translocation RCC, epithelioid angiomyolipoma, and unclassified RCC. In low-grade nonpapillary eosinophilic neoplasms, distinction between oncocytoma and low-grade RCC mostly rests on histomorphology; however, cytokeratin 7 immunostain may be helpful. In high-grade nonpapillary lesions, there is more of a role for ancillary techniques, including immunohistochemistry for cytokeratin 7, CA9, CD10, racemase, HMB45, and Melan-A. In papillary eosinophilic neoplasms, it is important to distinguish sporadic type 2 papillary RCC from microphthalmia transcription factor translocation and hereditary leiomyomatosis-associated RCC. Histologic and cytologic features along with immunohistochemistry and fluorescence in situ hybridization tests for TFE3 (Xp11.2) and TFEB [t(6;11)] are reliable confirmatory tests. Eosinophilic epithelial neoplasms with architecture, cytology, and/or immunoprofile not qualifying for either of the established types of RCC should be classified as unclassified eosinophilic RCC and arbitrarily assigned a grade (low or high).
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