ReviewJournal of perinatology : official journal of the California Perinatal Association2015
Oxygen targeting in preterm infants: a physiological interpretation.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review.Pediatrics · 2017Pooled it
- Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis.JAMA pediatrics · 2015Pooled it
- The Clinical Relevance of Overnight Oximetry in the Diagnosis of Intermittent Desaturations and the Need for Home Oxygen in the Near-Term and Term Infant.Children (Basel, Switzerland) · 2025Review
- The Utility of Umbilical Cord Pulse Oximetry-A Translational Study with Four Minutes of Deferred Cord Clamping Using an Asphyxiated Preterm Ovine Model.Children (Basel, Switzerland) · 2025Article
- Oxygen saturation targets in neonatal care: A narrative review.Early human development · 2024Review
- What is your optimal target of oxygen during general anesthesia in pediatric patients?Anesthesia and pain medicine · 2024Article
- Racial and skin color mediated disparities in pulse oximetry in infants and young children.Paediatric respiratory reviews · 2024Review
- A Bayesian Reanalysis of the Overall and Sex-Disaggregated Results of the Neonatal Oxygenation Prospective Meta-Analysis (NeOProM).Antioxidants (Basel, Switzerland) · 2024Article
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.Clinics in perinatology · 2024Review
- The impact of blood lactic acid levels on retinopathy of prematurity morbidity.BMC pediatrics · 2024Article
- LED light can falsify pulse oximetry readings via the stroboscopic effect.Physical and engineering sciences in medicine · 2023Article
- Lower pass threshold (≥93%) for critical congenital heart disease screening at high altitude prevents repeat screening and reduces false positives.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary Hypertension.Children (Basel, Switzerland) · 2021Article
- Inhaled Nitric Oxide at Birth Reduces Pulmonary Vascular Resistance and Improves Oxygenation in Preterm Lambs.Children (Basel, Switzerland) · 2021Article
- Accuracy of Pulse Oximetry in the Presence of Fetal Hemoglobin-A Systematic Review.Children (Basel, Switzerland) · 2021Review
- How Do We Monitor Oxygenation during the Management of PPHN? Alveolar, Arterial, Mixed Venous Oxygen Tension or Peripheral Saturation?Children (Basel, Switzerland) · 2020Review
- Optimal Oxygen Targets in Term Lambs with Meconium Aspiration Syndrome and Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2020Article
- The Various Oximetric Techniques Used for the Evaluation of Blood Oxygenation.Sensors (Basel, Switzerland) · 2020Review
- Thresholds for oximetry alarms and target range in the NICU: an observational assessment based on likely oxygen tension and maturity.BMC pediatrics · 2020Observational
- Oxygen therapy in preterm infants with pulmonary hypertension.Seminars in fetal & neonatal medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Randomized controlled trials evaluating low-target oxygen saturation (SpO2:85% to 89%) vs high-target SpO2 (91% to 95%) have shown variable results regarding mortality and morbidity in extremely preterm infants. Because of the variation inherent to the accuracy of pulse oximeters, the unspecified location of probe placement, the intrinsic relationship between SpO2 and arterial oxygen saturation (SaO2) and between SaO2 and partial pressure of oxygen (PaO2) (differences in oxygen dissociation curves for fetal and adult hemoglobin), the two comparison groups could have been more similar than dissimilar. The SpO2 values were in the target range for a shorter period of time than intended due to practical and methodological constraints. So the studies did not truly compare 'target SpO2 ranges'. In spite of this overlap, some of the studies did find significant differences in mortality prior to discharge, necrotizing enterocolitis and severe retinopathy of prematurity. These differences could potentially be secondary to time spent beyond the target range (SpO2 <85 or >95%) and could be avoided with an intermediate but wider target SpO2 range (87% to 93%). In conclusion, significant uncertainty persists about the desired target range of SpO2 in extremely preterm infants. Further studies should focus on studying newer methods of assessing oxygenation and strategies to limit hypoxemia (<85% SpO2) and hyperoxemia (>95% SpO2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.