Evidence map›Paper›PMID 25356869›Full record

ArticleCell death & disease2014

An eIF4E-interacting peptide induces cell death in cancer cell lines.

M Masse, V Glippa, H Saad, R Le Bloas, I Gauffeny, C Berthou, M Czjzek, P Cormier, B Cosson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. The coupling effect ofSynthetic and systems biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M Masse1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France.
V Glippa1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France.
H Saad1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France [4] Institut de Cancéro-hématologie, Département d'Hématologie, Hôpital Morvan, CHRU, Brest, France.
R Le Bloas1] Université Européenne de Bretagne, Brittany, France [2] Institut de Cancéro-hématologie, Département d'Hématologie, Hôpital Morvan, CHRU, Brest, France.
I Gauffeny1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France.
C Berthou1] Université Européenne de Bretagne, Brittany, France [2] Institut de Cancéro-hématologie, Département d'Hématologie, Hôpital Morvan, CHRU, Brest, France.
M Czjzek1] Université Européenne de Bretagne, Brittany, France [2] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Végétaux marins et biomolécules, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] CNRS, UMR 8227, Integrative Biology of Marine Models, Végétaux marins et biomolécules, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France.
P Cormier1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France.
B Cosson1] Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [2] CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, Roscoff cedex, France [3] Université Européenne de Bretagne, Brittany, France.
Université Européenne de Bretagne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. Abnormal regulation of eIF4E has been implicated in oncogenic transformation. We developed an eIF4E-binding peptide derived from Angel1, a partner of eIF4E that we recently identified. We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines. This necrotic cell death was characterized by a drop in ATP levels with F-actin network injury being a key step in extensive plasma membrane blebbing and membrane permeabilization. This synthetic eIF4E-binding peptide provides a candidate pharmacophore for a promising new cancer therapy strategy.

Indexed as

ActinsAnimalsCell DeathCell Line, TumorCell Membrane PermeabilityCell Membrane StructuresEukaryotic Initiation Factor-4EHumansNecrosisNeoplasmsPeptidesProtein BindingProtein BiosynthesisProtein StabilityRabbitsActinsEukaryotic Initiation Factor-4EPeptides

Identifiers

PMID25356869
PMCPMC4237268
OpenAlexW2002136337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.