ArticlePloS one2014
Separation of hepatic iron and fat by dual-source dual-energy computed tomography based on material decomposition: an animal study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Quantification of myocardial iron and fat-an experimental study with photon-counting detector CT.The British journal of radiology · 2026Article
- Liver fat quantification using deep silicon photon-counting CT: anRadiology advances · 2025Article
- Computed Tomography and Magnetic Resonance Imaging in Liver Iron Overload: From Precise Quantification to Prognosis Assessment.Biomedicines · 2024Review
- Virtual Non-Contrast versus True Native in Photon-Counting CT: Stability of Density of Upper Abdominal Organs and Vessels.Diagnostics (Basel, Switzerland) · 2024Article
- Non-Invasive Imaging Methods to Evaluate Non-Alcoholic Fatty Liver Disease with Fat Quantification: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Spectral CT: Current Liver Applications.Diagnostics (Basel, Switzerland) · 2023Review
- Pulse-Echo Quantitative US Biomarkers for Liver Steatosis: Toward Technical Standardization.Radiology · 2022Review
- Characterization of size-specific effects during dual-energy CT material decomposition of non-iodine materials.Journal of applied clinical medical physics · 2021Article
- Review
- Computed Tomography Techniques, Protocols, Advancements, and Future Directions in Liver Diseases.Magnetic resonance imaging clinics of North America · 2021Review
- Simultaneous hepatic iron and fat quantification with dual-energy CT in a rabbit model of coexisting iron and fat.Quantitative imaging in medicine and surgery · 2021Article
- Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement.Medical physics · 2020Review
- Dual-layer detector spectral CT versus magnetic resonance imaging for the assessment of iron overload in myelodysplastic syndromes and aplastic anemia.Japanese journal of radiology · 2020Article
- The influence of liver fat deposition on the quantification of the liver-iron fraction using fast-kilovolt-peak switching dual-energy CT imaging and material decomposition technique: anQuantitative imaging in medicine and surgery · 2019Article
- Comparison of Multimaterial Decomposition Fat Fraction with DECT and Proton Density Fat Fraction with IDEAL IQ MRI for Quantification of Liver Steatosis in a Population Exposed to Chemotherapy.Dose-response : a publication of International Hormesis SocietyArticle
- Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study.Dose-response : a publication of International Hormesis SocietyArticle
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3 authors.
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Abstract
objectiveTo explore the feasibility of dual-source dual-energy computed tomography (DSDECT) for hepatic iron and fat separation in vivo. MATERIALS AND
methodsAll of the procedures in this study were approved by the Research Animal Resource Center of Shanghai Ruijin Hospital. Sixty rats that underwent DECT scanning were divided into the normal group, fatty liver group, liver iron group, and coexisting liver iron and fat group, according to Prussian blue and HE staining. The data for each group were reconstructed and post-processed by an iron-specific, three-material decomposition algorithm. The iron enhancement value and the virtual non-iron contrast value, which indicated overloaded liver iron and residual liver tissue, respectively, were measured. Spearman's correlation and one-way analysis of variance (ANOVA) were performed, respectively, to analyze statistically the correlations with the histopathological results and differences among groups.
resultsThe iron enhancement values were positively correlated with the iron pathology grading (r = 0.729, p<0.001). Virtual non-iron contrast (VNC) values were negatively correlated with the fat pathology grading (r = -0.642,p<0.0001). Different groups showed significantly different iron enhancement values and VNC values (F = 25.308,p<0.001; F = 10.911, p<0.001, respectively). Among the groups, significant differences in iron enhancement values were only observed between the iron-present and iron-absent groups, and differences in VNC values were only observed between the fat-present and fat-absent groups.
conclusionSeparation of hepatic iron and fat by dual energy material decomposition in vivo was feasible, even when they coexisted.
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