ArticleEnvironmental health perspectives2015
Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence.International journal of environmental research and public health · 2024Pooled it
- Associations of Maternal Urinary Cadmium with Trimester-Specific Blood Pressure in Pregnancy: Role of Dietary Intake of Micronutrients.Biological trace element research · 2016Trial
- Potentially Toxic Elements-mediated Toxicity on Vagus Nerve and Cellular Energy Expenditure in Noncommunicable Diseases: A Systematic Review and Evidence Map.Biological trace element research · 2026Review
- Associations of co-exposure to metals and polycyclic aromatic hydrocarbons with aging biomarkers: insights from epidemiology and network toxicology.Frontiers in public health · 2026Article
- Exposure to Multiple Metal(loid)s and Hypertension in Chinese Older Adults.Biological trace element research · 2025Article
- Inflammatory and metabolic markers mediate the association between urinary metals and non-alcoholic fatty liver disease in U.S. adults: a cross-sectional study.Frontiers in public health · 2025Article
- Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Update: factors influencing heart rate variability-a narrative review.Frontiers in physiology · 2024Review
- Article
- The association between urinary metals/metalloids and chronic kidney disease among general adults in Wuhan, China.Scientific reports · 2023Article
- Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2023Article
- Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females.Environmental science and pollution research international · 2022Article
- Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China.Environmental science and pollution research international · 2022Article
- Comparison of Urinary Heavy Metals and Pulmonary Function Test in Cafe Workers Based on Exposure to Secondhand Tobacco Smoke, Tehran 2021.International journal of preventive medicine · 2022Article
- Protective Effects of Sodium Para-aminosalicylic Acid on Manganese-Induced Damage in Rat Pancreas.Biological trace element research · 2021Article
- Sources of 24-h personal exposure to PMEnvironmental science and pollution research international · 2021Article
- Personal exposure to PMEnvironmental science and pollution research international · 2021Article
- The Association Between Trace Elements Exposure and the Cognition in the Elderly in China.Biological trace element research · 2021Article
- Urinary Oxidative Stress Biomarkers in Workers of a Titanium Dioxide Based Pigment Production Plant.International journal of environmental research and public health · 2020Article
- A case-control study of arsenic exposure with the risk of primary ovarian insufficiency in women.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, studies on the association between internal assessments of metals exposure and HRV are limited.
objectivesThe purpose of this study was to examine the potential association between urinary metals and HRV among residents of an urban community in Wuhan, China.
methodsWe performed a cross-sectional analysis of 23 urinary metals and 5-min HRV indices (SDNN, standard deviation of normal-to-normal intervals; r-MSSD, root mean square of successive differences in adjacent normal-to-normal intervals; LF, low frequency; HF, high frequency; TP, total power) using baseline data on 2,004 adult residents of Wuhan.
resultsAfter adjusting for other metals, creatinine, and other covariates, natural log-transformed urine titanium concentration was positively associated with all HRV indices (all p < 0.05). Moreover, we estimated negative associations between cadmium and r-MSSD, LF, HF, and TP; between lead and r-MSSD, HF, and TP; and between iron, copper, and arsenic and HF, SDNN, and LF, respectively, based on models adjusted for other metals, creatinine, and covariates (all p < 0.10). Several associations differed according to cardiovascular disease risk factors. For example, negative associations between cadmium and r-MSSD were stronger among participants ≤ 52 years of age (vs. > 52), current smokers (vs. nonsmokers), body mass index < 25 kg/m2 (vs. ≥ 25), and among those who were not hypertensive.
conclusionsUrine concentrations of several metals were associated with HRV parameters in our cross-sectional study population. These findings need replication in other studies with adequate sample sizes.
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