ArticlePloS one2014
Bisphenol A exposure and asthma development in school-age children: a longitudinal study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Temporal and geographic variability of bisphenol levels in humans: A systematic review and meta-analysis of international biomonitoring data.Environmental research · 2025Pooled it
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Characterizing changes in behaviors associated with chemical exposures during the COVID-19 pandemic.PloS one · 2023Article
- Prenatal and postnatal exposure to Bisphenol A and Asthma: a systemic review and meta-analysis.Journal of thoracic disease · 2021Article
- Exposure to bisphenols and asthma morbidity among low-income urban children with asthma.The Journal of allergy and clinical immunology · 2021Article
- Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes.Environmental research · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma.
objectiveWe hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma.
methodsParticipants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model.
resultsThe log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P = .02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P<.001) at ages up to 11-12 years. Bisphenol A was also negatively associated with PC20 (ß = -2.33; P = .02). When stratified by sex, the association between bisphenol A and asthma remained significant only in girls (hazard ratio, 2.45; 95% confidence interval, 2.18-2.76; P<.001).
conclusionIncreased urinary bisphenol A concentrations at 7-8 years old were positively associated with wheezing and asthma and negatively associated with PC20 at ages up to 11-12 years.
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