Trial reportJAMA otolaryngology-- head & neck surgery2015
A novel treatment for tinnitus and tinnitus-related cognitive difficulties using computer-based cognitive training and D-cycloserine.
Trial report in JAMA otolaryngology-- head & neck surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01550796 (Treatment of Chronic Bothersome Tinnitus Using Cognitive Training and D-cycloserine), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Chronic Bothersome Tinnitus Using Cognitive Training and D-cycloserine
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- The Association Between Effectiveness of Tinnitus Intervention and Cognitive Function-A Systematic Review.Frontiers in psychology · 2020Pooled it
- Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses.Trends in hearingPooled it
- Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2018Trial
- Cognitive Training for Adults With Bothersome Tinnitus: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2017Trial
- Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study.American journal of otolaryngologyTrial
- Testing A Hypothesis: Tinnitus Control by Enhancing Physiological Inhibition.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Development and Preliminary Evaluation of the Tinnitus Severity Short Form.American journal of audiology · 2021Article
- Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population.Hearing research · 2016Article
- Polish Translation and Validation of the Tinnitus Handicap Inventory and the Tinnitus Functional Index.Frontiers in psychology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
importanceTinnitus affects more than 40 million people in the Unites States, and cognitive difficulties are among the most commonly associated symptoms.
objectiveTo test the feasibility and preliminarily the effectiveness of using a putative neuroplasticity-enhancing drug, D-cycloserine, to facilitate a computer-assisted CT program for improving tinnitus bother and related cognitive difficulties. DESIGN, SETTING, AND
participantsDouble-blind, randomized clinical trial at an outpatient academic medical center of 34 participants aged 35 to 65 years with subjective, unilateral or bilateral, nonpulsatile tinnitus of at least 6 months' duration.
interventionsFive weeks of twice-weekly computer-based CT with either 250 mg D-cycloserine or placebo orally prior to computer CT sessions. MAIN OUTCOMES AND MEASURES: Difference in the change in Tinnitus Functional Index (TFI) score between the 2 groups.
resultsAfter excluding 1 participant lost to follow-up, 1 who withdrew, 1 who did not complete 90% of sessions, and 1 outlier, 30 participants were included in the analysis. The D-cycloserine plus CT group showed a significant improvement in median TFI score (-5.8 [95% CI, -9.4 to -1.1]) and self-reported cognitive deficits (-4.5 [95% CI, -11.5 to -1.0]), but the placebo group did not (-1.0 [95% CI, -11.7 to 4.9] and -2.0 [95% CI, -5.1 to 2.0], respectively). After controlling for age and duration of tinnitus, there was no significant difference in TFI score change between the 2 groups (P = .41). After confounders were controlled for, the D-cycloserine group demonstrated a significantly greater improvement in self-reported cognitive deficits as compared with the placebo group (P = .03). No serious adverse events were reported. CONCLUSIONS AND RELEVANCE: Use of a computer-based CT program with a putative neuroplasticity-sensitizing drug, D-cycloserine, was feasible and well tolerated. With the limited sample size, the adjuvant use of D-cycloserine was no more effective than placebo at improving tinnitus bother. The finding that D-cycloserine use was more effective than placebo at improving self-reported cognitive difficulties could be important given the high rate of concern for cognitive deficits in patients with tinnitus. D-cycloserine and other putative neuroplasticity-facilitating agents could be investigated in the future as a strategy to enhance neuroplasticity-based tinnitus treatments.
trial registrationclinicaltrials.gov Identifier: NCT01550796.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.