ArticleAnnals of clinical and translational neurology2014
Multiple prior concussions are associated with symptoms in high school athletes.
Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Psychiatric, Psychological, and Behavioural Outcomes following Mild Traumatic Brain Injury in Children and Adolescents.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Pooled it
- Behavioral hyperactivity and hippocampal mitochondrial dysfunction following recurrent concussions in young mice.Molecular and cellular biochemistry · 2026Article
- Clinical Cut Point for the Postconcussion Symptom Inventory Following Adolescent Concussion.Medicine and science in sports and exercise · 2026Article
- Attention-Deficit/Hyperactivity Disorder as a Mediating Variable for Invalid Baseline Profiles on the ImPACT.Healthcare (Basel, Switzerland) · 2025Article
- Variables associated with days of school missed following concussion: results from the Sport Concussion Outcomes in PEdiatrics (SCOPE) study.The Physician and sportsmedicine · 2024Article
- Collegiate Adapted Athlete Baseline Performance on the Vestibular/Ocular Motor Screening.Journal of athletic training · 2024Article
- Accommodative and Vergence Responses to a Moving Stimulus in Concussion.Investigative ophthalmology & visual science · 2024Article
- The role of concussion history and biological sex on baseline concussion clinical profile symptoms in adolescent rugby players.Irish journal of medical science · 2024Article
- Frequency of low ImPACT scores among adolescent and young adult student-athletes with attention-deficit/hyperactivity disorder and/or learning disorder.Frontiers in neurology · 2024Article
- Effects of a history of headache and migraine treatment on baseline neurocognitive function in young athletes.The journal of headache and pain · 2022Article
- Investigating the overlapping associations of prior concussion, default mode connectivity, and executive function-based symptoms.Brain imaging and behavior · 2022Article
- Longitudinal trajectory of depression symptom severity and the influence of concussion history and physical function over a 19-year period among former National Football League (NFL) players: an NFL-LONG Study.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Impairment of cerebrovascular reactivity in response to hypercapnic challenge in a mouse model of repetitive mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- A Normative Reference vs. Baseline Testing Compromise for ImPACT: The CARE Consortium Multiple Variable Prediction (CARE-MVP) Norms.Sports medicine (Auckland, N.Z.) · 2020Article
- The neurobiological effects of repetitive head impacts in collision sports.Neurobiology of disease · 2019Review
- Multiple Past Concussions in High School Football Players: Are There Differences in Cognitive Functioning and Symptom Reporting?The American journal of sports medicine · 2016Article
- Concussion-Like Symptoms in Child and Youth Athletes at Baseline: What Is "Typical"?Journal of athletic training · 2016Article
- Football Players' Head-Impact Exposure After Limiting of Full-Contact Practices.Journal of athletic training · 2016Article
- Thinner Cortex in Collegiate Football Players With, but not Without, a Self-Reported History of Concussion.Journal of neurotrauma · 2016Article
- Factors Associated With Concussion-like Symptom Reporting in High School Athletes.JAMA pediatrics · 2015Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to evaluate the association of prior concussion on baseline computerized neurocognitive testing in a large cohort of high school athletes.
methodsThis is a retrospective cohort study of student athletes from 49 Maine High Schools in 2010 who underwent baseline computerized neurocognitive evaluation with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®). As part of the ImPACT®, subjects reported a prior history of concussion as well as demographic information and a symptom questionnaire. We used linear regression to evaluate the association of prior concussion with baseline: (1) ImPACT® composite scores; and (2) symptom scores.
resultsSix thousand seventy-five subjects were included in the study, of whom 57% were boys. The majority of student athletes (85.3%) reported no prior history of concussion while 4.6% reported having sustained two or more prior concussions. On simple linear regression, increasing number of concussions was related to worse performance in verbal memory (P = 0.039) and greater symptoms scores (P < 0.001). On multivariate modeling, only the association with baseline symptoms remained (P < 0.001). Other factors associated with baseline symptom reporting in the multivariate model included mental health history, headache/migraine history, gender, developmental and/or learning problems, and number of prior concussions.
interpretationIn this large-scale, retrospective survey study, history of multiple prior concussions was associated with higher symptom burden but not baseline computerized neurocognitive testing. The association between baseline symptom reporting and clinical and demographic factors was greater than the association with a history of multiple concussions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.