Evidence map›Paper›PMID 25356375›Full record

ArticleOtolaryngology (Sunnyvale, Calif.)2012

Plasticity in the Primary Auditory Cortex, Not What You Think it is: Implications for Basic and Clinical Auditory Neuroscience.

Norman M Weinberger

Abstract read
In one paragraph

Article in Otolaryngology (Sunnyvale, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Norman M WeinbergerCenter for the Neurobiology of Learning and Memory, Center for Hearing Research, and Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.

Funding

DYNAMIC REGULATION OF TUNING IN ADULT AUDITORY CORTEXR01DC002938 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 1997 to 2015
$4.1M
Functions of Associative Auditory Cortical PlasticityR01DC010013 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WEINBERGER, NORMAN M · 2009 to 2013
$1.5M
Dynamic Regulation of Tuning in Adult Auditory CortexR56DC002938 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WEINBERGER, NORMAN M · 2008 to 2008
$370k
NIDCD NIH HHS R01 DC002938NIDCD NIH HHS R01 DC010013NIDCD NIH HHS R56 DC002938
6 · The paper itself

Abstract

Standard beliefs that the function of the primary auditory cortex (A1) is the analysis of sound have proven to be incorrect. Its involvement in learning, memory and other complex processes in both animals and humans is now well-established, although often not appreciated. Auditory coding is strongly modifed by associative learning, evident as associative representational plasticity (ARP) in which the representation of an acoustic dimension, like frequency, is re-organized to emphasize a sound that has become behaviorally important. For example, the frequency tuning of a cortical neuron can be shifted to match that of a significant sound and the representational area of sounds that acquire behavioral importance can be increased. ARP depends on the learning strategy used to solve an auditory problem and the increased cortical area confers greater strength of auditory memory. Thus, primary auditory cortex is involved in cognitive processes, transcending its assumed function of auditory stimulus analysis. The implications for basic neuroscience and clinical auditory neuroscience are presented and suggestions for remediation of auditory processing disorders are introduced.

Indexed as

AcetylcholineCognitive processesLearningLearning strategyMemory codeReceptive field

Identifiers

PMID25356375
PMCPMC4209739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.