Evidence map›Paper›PMID 25356302›Full record

ReviewSexual medicine2014

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE).

Stanley E Althof, Chris G McMahon, Marcel D Waldinger, Ege Can Serefoglu, Alan W Shindel, P Ganesan Adaikan, Edgardo Becher, John Dean, Francois Giuliano, Wayne Jg Hellstrom and 10 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sexual medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02572037 completednot on this mapstarted 2015, after this paper: background citation

Research and Clinical Value of New Classification for Premature Ejaculation:Multi-Center Research

TypeobservationalSponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2015 to 2017Enrolled568ConditionsPremature Ejaculation
NCT07067970 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of the Efficacy and Safety of Dapoxetine, Kegel Exercises, and Acupuncture in the Treatment of Premature Ejaculation: A Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorMedipol UniversityRan2025 to 2026Enrolled250ConditionsPremature EjaculationArmsserotonin reuptake inhibitor (SSRI), Placebo, Acupuncture, Sham, Exercise
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Stanley E AlthofDepartment of Psychiatry, Case Western Reserve University School of Medicine West Palm Beach, FL, USA.
Chris G McMahonAustralian Center for Sexual Health Sydney, NSW, Australia.
Marcel D WaldingerDivision of Pharmacology, Department of Pharmaceutical Sciences, Utrecht University Utrecht, The Netherlands.
Ege Can SerefogluDepartment of Urology, Bagcilar Training & Research Hospital Istanbul, Merkez Mah, Turkey.
Alan W ShindelDepartment of Urology, University of California at Davis CA, USA.
P Ganesan AdaikanDepartment of Obstetrics and Gynecology, National University of Singapore Singapore, Singapore.
Edgardo BecherDivision of Urology, University of Buenos Aires Buenos Aires, Argentina.
John DeanSt. Peter's Sexual Medicine, The London Clinic London, UK.
Francois GiulianoNeuro-Uro-Andrology, Physical Medicine and Rehabilitation Department, Raymond Poincaré Hospital Garches, France.
Wayne Jg HellstromDepartment of Urology, Tulane University Health Sciences Center New Orleans, LA, USA.
Annamaria GiraldiDepartment of Sexological Research, Psychiatric Center Copenhagen, Rigshospitalet Copenhagen, Denmark.
Sidney GlinaDepartment of Urology, Instituto H. Ellis Sao Paulo, Brazil.
Luca IncrocciErasmus MC-Daniel den Hoed Cancer Center Rotterdam, The Netherlands.
Emmanuele JanniniSchool of Sexology, Department of Clinical, Applied and Biotechnological Sciences, University of L'Aquila L'Aquila, Italy.
Marita McCabeSchool of Psychology, Deakin University Burwood, Vic., Australia.
Sharon ParishAlbert Einstein College of Medicine, Department of Medicine, Montefiore Medical Center Bronx, NY, USA.
David RowlandGraduate School, Valparaiso University Valparaiso, IN, USA.
R Taylor SegravesDepartment of Psychiatry, Case Western Reserve University School of Medicine Cleveland, OH, USA.
Ira SharlipDepartment of Urology, University of California San Francisco, CA, USA.
Luiz Otavio TorresClinica de Urologia e Andrologia Belo-Horizonte, Minas-Gerais, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts.

aimThe aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts.

methodA comprehensive literature review was performed.

resultsThis article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients.

conclusionDevelopment of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60-90.

Indexed as

Definition of PEDiagnosis of PEEtiology of PEPharmacotherapy of PEPremature EjaculationPrevalence of PEPsychotherapy of PE

Identifiers

PMID25356302
PMCPMC4184677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.