Evidence map›Paper›PMID 25356211›Full record

ArticleClinical case reports2013

Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization.

Akira Namba, Miyuki Nishiyama, Joseph J Weiser, Phillip Wyatt, Machiko Kimura, Rei Niizawa, Akinori Miki, Osamu Ishihara, Atsuo Itakura, Yoshimasa Kamei

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akira NambaDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Miyuki NishiyamaLabCorp Japan Chuo-ku, Tokyo, Japan.
Joseph J WeiserIntegrated Genetics Santa Fe, New Mexico.
Phillip WyattIntegrated Genetics Santa Fe, New Mexico.
Machiko KimuraDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Rei NiizawaDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Akinori MikiDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Osamu IshiharaDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Atsuo ItakuraDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.
Yoshimasa KameiDepartment of Obstetrics and Gynecology, Saitama Medical University Iruma-gun, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key clinical messageMaternal serum screening-positive patient had prenatal diagnosis with amniotic fluid, which showed inconsistent results between interphase fluorescence in situ hybridization (three signals of 21q22.13-21q22.2) and G-banding analysis (46,XY). Further analyses proved that the fetus had extremely complex rearrangements of chromosome 21, including the interstitial duplication of Down syndrome critical region.

Indexed as

aCGHchromosome 21Down syndromeDSCRinterphase FISHmetaphase FISH

Identifiers

PMID25356211
PMCPMC4184748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.