ArticleInternational journal of clinical and experimental medicine2014
Inflammatory and bone turnover markers in relation to PTH and vitamin D status among Saudi postmenopausal women with and without osteoporosis.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A meta-analysis of serum osteocalcin level in postmenopausal osteoporotic women compared to controls.BMC musculoskeletal disorders · 2019Pooled it
- High-fat diet-induced osteoporosis in mice under hypoxic conditions.BMC musculoskeletal disorders · 2025Article
- Observational
- Combined Effect of Dietary Acid Load and Cardiometabolic Syndrome on Bone Resorption Marker among Post-Menopausal Women in Malaysia.The Malaysian journal of medical sciences : MJMS · 2024Article
- Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases.Journal of molecular medicine (Berlin, Germany) · 2024Review
- The role of bone turnover markers in screening low bone mineral density and their relationship with fracture risk in the postmenopausal period.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Associations Between Inflammatory Mediators and Bone Outcomes in Postmenopausal Women: A Cross-Sectional Analysis of Baseline Data from the Prune Study.Journal of inflammation research · 2023Article
- The Effect of Selected Herbal Medicines on Bone Turnover Markers: A Systematic Review and Meta-Analysis.Journal of family & reproductive health · 2022Review
- Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis.Journal of osteoporosis · 2022Article
- Prevalence of Vertebral Fractures and Their Prognostic Significance in the Survival in Patients with Chronic Kidney Disease Stages 3‒5 Not on Dialysis.Journal of clinical medicine · 2020Article
- Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women.Bioscience reports · 2020Observational
- Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health.Frontiers in endocrinology · 2020Article
- Dietary Acid Load, IGF-1 Single Nucleotide Polymorphism and Bone Resorption among Postmenopausal Chinese Women.Nutrients · 2018Article
- Correlations between posterior longitudinal ligament status and size of bone fragment in thoracolumbar burst fractures.International journal of clinical and experimental medicine · 2015Article
- Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats.PloS one · 2015Article
- Interplay of Vitamin D, Inflammation, and Bone Health in Emirati Patients with Type 2 Diabetes: A Cross-sectional Study.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postmenopausal osteoporosis is characterized by rapid bone loss occurring in the post-menopausal period. The bone loss predominantly involves the trabecular bone and is brought about by an imbalance between the bone remodeling process which can be influenced by factors that could cause or contribute to osteoporosis. Pro-inflammatory cytokines (Il-1β, Il-6, IL-8 and TNF-α) have been implicated in the regulation of bone cells and play a critical role in bone remodeling. They act both directly and indirectly to increase bone resorption, and/or inhibit bone formation. The aim of the study is to determine whether pro-inflammatory cytokines correlate with bone turnover markers (BTM) in a cohort of Saudi post-menopausal women with or without osteoporosis and which BTMs will correlate with PTH and Vitamin D for use in osteoporosis diagnosis. The study is composed of 100 post-menopausal patients and 100 controls aged 50 years and above. Serum concentrations of pro-inflammatory and BTMs as well as PTH and vitamin D were determined by ELISA, Luminex and electrochemiluminescence. Serum calcium, phosphorus, glucose, and lipid profile were measured by using a chemical analyzer. There was a significant increase in the levels of pro-inflammatory cytokines, PTH, CTx, and glucose. A significantly lower vitamin D and osteocalcin levels were observed in subjects with osteoporosis than those without. No significant differences were recorded in the circulating lipid profile between groups. The present study proved that the pro-inflammatory cytokines accelerate the bone loss in postmenopausal women.
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Identifiers
25356143PMC4211793W1948385379What OpenQuestion holds
Registered trials
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