ArticleInternational journal of clinical and experimental medicine2014
Interleukin 6 increases dysfunction of organs in sepsis rats through sirtuin 1.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Effective management of pediatric septic shock: a case study utilizing continuous renal replacement therapy with cytosorb and citrate in a leukemic patient with hyper-interleukin (IL)-6-naemia and severe thrombocytopenia.BMC infectious diseases · 2025Article
- Melatonin Mediates Cardiac Tissue Damage under Septic Conditions Induced by Lipopolysaccharide.International journal of molecular sciences · 2024Article
- Analysis of histopathology and changes of major cytokines in the lesions caused by Mycoplasma ovipneumoniae infection.BMC veterinary research · 2023Article
- A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.PloS one · 2021Article
- Diagnostic performance of interleukin-6 and interleukin-8 for bacterial meningitis: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis-induced organ failure is the major cause of death, and is characterized by a massive dysregulated inflammatory response. The present study was to determine whether interleukin 6 (IL-6) expression was increased in sepsis rats and the roles of IL-6 in the damage of cardiac, liver and renal function in the sepsis rats. Sepsis rat models were elicited by intravenous injection of LPS. The mRNA and protein of IL-6 levels were increased in the sepsis rats. The Left ventricular developed pressure (LVDP) and average ±dP/dt were significantly reduced in sepsis rats compare with sham group. ALT and AST activities and creatinine level were increased in the sepsis rats. IL-6 significantly reduced LVDP and average ±dP/dt, increased the activities of ALT and AST, and increased the concentration of creatinine in the sepsis rats. EX527, a sirtuin 1 (SIRT 1) inhibitor, blocked the effects of IL-6 in the sepsis rats. These results indicate that IL-6 plays important roles in the damage of cardiac, liver and renal function in the sepsis rats through SIRT 1.
Indexed as
Identifiers
25356114PMC4211764W2139161529What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.