Evidence map›Paper›PMID 25356092›Full record

ReviewInternational journal of clinical and experimental medicine2014

Concept of the aortic aneurysm repair-related surgical stress: a review of the literature.

Demetrios N Moris, Michalis I Kontos, Eleftherios I Mantonakis, Antonios K Athanasiou, Eleftherios D Spartalis, Chris N Bakoyiannis, George P Chrousos, Sotirios E Georgopoulos

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894864 (Effect of a Perioperative Opioid Free Anesthesia-Analgesia), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04894864 phase4recruitingnot on this mapstarted 2020, after this paper: background citation

Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study

TypeinterventionalSponsorUniversity of CreteRan2020 to 2027Enrolled40ConditionsElective Surgical Procedures, Postoperative Pain, Anesthesia, Opioid UseArmsOpioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Demetrios N MorisThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Michalis I KontosThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Eleftherios I MantonakisThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Antonios K AthanasiouThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Eleftherios D SpartalisThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Chris N BakoyiannisThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
George P ChrousosDivision of Endocrinology, Metabolism and Diabetes, University of Athens Medical School, Aghia Sophia Children's Hospital Athens, Greece.
Sotirios E GeorgopoulosThe First Department of Surgery, Division of Vascular Surgery, "Laiko" General Hospital, Medical School, National and Kapodistrian University of Athens Athens, Greece.
Laiko General Hospital of Athens · GRChildren's Hospital Agia Sophia · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAbdominal aorta aneurysm (AAA) is a serious threat for human life. AAA repair is a high-risk procedure which results in a severe surgical stress response. We aim to give a conceptual description of the underlying pathophysiology of stress after surgical repair of AAA.

methodsThe MEDLINE/PubMed database was searched for publications with the medical subject heading "surgical stress" and keywords "abdominal aortic aneurysms (AAA)", or "cytokines" or "hormones" or "open repair (OR)" or "endovascular repair (EVAR)". We restricted our search to English till 2012 and only in cases of abdominal and thoracoabdominal aneurysms (TAAA).

resultsWe identified 93 articles that were available in English as abstracts or/and full-text articles that were deemed appropriate for our review.

conclusionsLiterature highlights no statistical significance for early acute TNF-α production in EVAR and no TNF-α production in OR. IL-6 and IL-8 levels are higher after OR especially when compared with those of EVAR. IL-10 peak was observed during ischemic phase in aneurysm surgical repair. Cortisol and epinephrine levels are higher in OR patients in comparison to EVAR patients. Finally, the incidence of systemic inflammatory response syndrome was significantly higher in OR than EVAR patients.

Indexed as

abdominal aortic aneurysms (AAA)cytokinesendovascular repair (EVAR)hormonesopen repair (OR)Surgical stress

Identifiers

PMID25356092
PMCPMC4211742
OpenAlexW114027165

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.