Evidence map›Paper›PMID 25356091›Full record

ArticleElectronic journal of statistics2014

Dynamic treatment regimes: technical challenges and applications.

Eric B Laber, Daniel J Lizotte, Min Qian, William E Pelham, Susan A Murphy

Abstract read
In one paragraph

Article in Electronic journal of statistics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Deeply Tailored Adaptive Interventions to Reduce College Student Drinking: a Real-World Application of Q-Learning for SMART Studies.Prevention science : the official journal of the Society for Prevention Research · 2022
    Trial
  2. Trial
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  5. Replicable Bandits for Digital Health Interventions.Statistical science : a review journal of the Institute of Mathematical Statistics · 2025
    Article
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  16. Outcome trajectory estimation for optimal dynamic treatment regimes with repeated measures.Journal of the Royal Statistical Society. Series C, Applied statistics · 2023
    Article
  17. Observational
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric B LaberNorth Carolina State University, Raleigh, NC 27696-8203.
Daniel J LizotteUniversity of Waterloo, Waterloo, Ontario N2L 3G1.
Min QianColumbia University, New York, NY 10032.
William E PelhamFlorida International University, Miami, FL 33199.
Susan A MurphyUniversity of Michigan, Ann Arbor, MI 48106-1248.

Funding

THE REFINEMENT &APPLICATION OF MEDICAL DECISION MAKING IN PREVENTION SCIENCESP50DA010075 · NIDA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LANZA, STEPHANIE T · 1996 to 2014
$24.5M
Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSIATIS, ANASTASIOS A · 2010 to 2019
$21.3M
Adaptive Interventions for Minimally Verbal Children with ASD in the CommunityR01HD073975 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2012 to 2016
$13.0M
TRAINING U54EB020404 · NIBIB · UNIVERSITY OF MEMPHIS · PI KUMAR, SANTOSH · 2014 to 2018
$11.3M
Learning Adaptive Treatment Strategies in Mental HealthR01MH080015 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, SUSAN A · 2007 to 2011
$2.2M
Improving Mental Health Outcomes: Buidling an Adaptive Implementation StrategyR01MH099898 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KILBOURNE, AMY M · 2014 to 2017
$1.9M
NCI NIH HHS P01 CA142538NIBIB NIH HHS U54 EB020404NICHD NIH HHS R01 HD073975NIDA NIH HHS P50 DA010075NIMH NIH HHS R01 MH080015NIMH NIH HHS R01 MH099898
6 · The paper itself

Abstract

Dynamic treatment regimes are of growing interest across the clinical sciences because these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. Formally, a dynamic treatment regime is a sequence of decision rules, one per stage of clinical intervention. Each decision rule maps up-to-date patient information to a recommended treatment. We briefly review a variety of approaches for using data to construct the decision rules. We then review a critical inferential challenge that results from nonregularity, which often arises in this area. In particular, nonregularity arises in inference for parameters in the optimal dynamic treatment regime; the asymptotic, limiting, distribution of estimators are sensitive to local perturbations. We propose and evaluate a locally consistent Adaptive Confidence Interval (ACI) for the parameters of the optimal dynamic treatment regime. We use data from the Adaptive Pharmacological and Behavioral Treatments for Children with ADHD Trial as an illustrative example. We conclude by highlighting and discussing emerging theoretical problems in this area.

Indexed as

Adaptive confidence intervalsData-driven decision makingNonregular inferencePersonalized medicine

Identifiers

PMID25356091
PMCPMC4209714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.