Evidence map›Paper›PMID 25356027›Full record

GuidelineWorld journal of gastroenterology2014

Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: an Italian position statement.

Gianni Testino, Patrizia Burra, Ferruccio Bonino, Francesco Piani, Alessandro Sumberaz, Roberto Peressutti, Andrea Giannelli Castiglione, Valentino Patussi, Tiziana Fanucchi, Ornella Ancarani and 15 more

Abstract readPractice GuidelineReview
In one paragraph

Guideline in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  8. Article
  9. Article
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  11. Expert perspectives for the pharmacist on facilitating and improving the use of albumin in cirrhosis.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023
    Review
  12. The Hepatorenal Syndrome Patient Pathway: Retrospective Analysis of Electronic Health Records.Current therapeutic research, clinical and experimental · 2022
    Article
  13. Review
  14. The Current Management of Hepatorenal Syndrome-Acute Kidney Injury in the United States and the Potential of Terlipressin.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2021
    Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Gianni TestinoGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Patrizia BurraGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Ferruccio BoninoGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Francesco PianiGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Alessandro SumberazGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Roberto PeressuttiGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Andrea Giannelli CastiglioneGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Valentino PatussiGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Tiziana FanucchiGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Ornella AncaraniGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Giovanna De CerceGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Anna Teresa IanniniGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Giovanni GrecoGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Antonio MostiGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Marilena DuranteGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Paola BabocciGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Mariano QuartiniGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Davide MioniGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Sarino AricòGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Aniello BaseliceGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Silvia LeoneGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Fabiola LozerGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Emanuele ScafatoGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Paolo BorroGianni Testino, Paolo Borro, Alessandro Sumberaz, Ornella Ancarani, Regional Alcohologic Centre, Liguria Region, Alcohol Unit and Related Diseases, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-IST National Institute for Cancer Research, 16100 Genova, Italy.
Group of Italian Regions

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attributed to alcohol. Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation (LT). The vast majority of transplant programmes (85%) require 6 mo of abstinence prior to transplantation; commonly referred to as the "6-mo rule". Both in the case of progressive end-stage liver disease (ESLD) and in the case of severe acute alcoholic hepatitis (AAH), not responding to medical therapy, there is a lack of evidence to support a 6-mo sobriety period. It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking. The "Group of Italian Regions" suggests that: in a case of ESLD with model for end-stage liver disease < 19 a 6-mo abstinence period is required; in a case of ESLD, a 3-mo sober period before LT may be more ideal than a 6-mo period, in selected patients; and in a case of severe AAH, not responding to medical therapies (up to 70% of patients die within 6 mo), LT is mandatory, even without achieving abstinence. The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist. Patients have to participate in self-help groups.

Indexed as

Alcohol AbstinenceComorbidityHepatitis, AlcoholicHumansItalyLiver Cirrhosis, AlcoholicLiver TransplantationPatient Care TeamPatient SelectionRisk AssessmentRisk FactorsSelf-Help GroupsSeverity of Illness IndexTime FactorsTreatment OutcomeWaiting ListsAlcoholAlcoholic hepatitisCirrhosisHepatocellular carcinomaLiver transplantation

Identifiers

PMID25356027
PMCPMC4209530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.