ArticleAJNR. American journal of neuroradiology2015
Crossed cerebrocerebellar language lateralization: an additional diagnostic feature for assessing atypical language representation in presurgical functional MR imaging.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intraoperative neurophysiology of the cerebellum: a tabula rasa.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Pooled it
- Assessing Language Lateralization through Gray Matter Volume: Implications for Preoperative Planning in Brain Tumor Surgery.Brain sciences · 2024Article
- Functional MRI but not white matter fibre dissection identifies language dominance.European radiology · 2023Article
- BOLD fMRI and DTI fiber tracking for preoperative mapping of eloquent cerebral regions in brain tumor patients: impact on surgical approach and outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Clinical Speech fMRI in Children and Adolescents : Development of an Optimal Protocol and Analysis Algorithm.Clinical neuroradiology · 2022Article
- Resting-state functional MRI language network connectivity differences in patients with brain tumors: exploration of the cerebellum and contralesional hemisphere.Brain imaging and behavior · 2022Article
- Alternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients.European radiology · 2022Article
- Presurgical Language fMRI in Children, Adolescents and Young Adults : A Validation Study.Clinical neuroradiology · 2020Article
- Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy.Seizure · 2020Review
- Biometry of the Cerebellar Vermis and Brain Stem in Children: MR Imaging Reference Data from Measurements in 718 Children.AJNR. American journal of neuroradiology · 2019Article
- Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables.Neurology research international · 2019Article
- Paradoxical Activation in the Cerebellum During Language fMRI in Patients with Brain Tumors: Possible Explanations Based on Neurovascular Uncoupling and Functional Reorganization.Cerebellum (London, England) · 2018Article
- Differential Effects of Awake Glioma Surgery in "Critical" Language Areas on Cognition: 4 Case Studies.Case reports in neurological medicine · 2017Article
- The diminishing dominance of the dominant hemisphere: Language fMRI in focal epilepsy.NeuroImage. Clinical · 2017Article
- fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: a comparison with Broca's area.Neuroradiology · 2016Article
- Cerebellar mutism.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Atypical cerebral and cerebellar language organisation: a case study.Cerebellum & ataxias · 2015Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeDetermining language dominance with fMRI is challenging in patients with brain tumor, particularly in cases of suspected atypical language representation. Supratentorial activation patterns must be interpreted with great care when the tumor is in or near the presumed language areas, where tumor tissue or mass effect can lead to false-negative fMRI results. In this study, we assessed cerebrocerebellar language fMRI lateralization in healthy participants and in patients with brain tumors with a focus on atypical language representation. MATERIALS AND
methodsTwenty healthy participants and 38 patients with a brain tumor underwent fMRI with a verb-generation task. Cerebral and cerebellar language lateralizations were separately classified as left-sided, right-sided, or symmetric. Electrocortical stimulation was performed in 19 patients. With the McNemar test, we evaluated the dependency between language lateralization in the cerebrum and cerebellum, and with Pearson correlation analysis, the relationship between the cerebral and cerebellar lateralization indices.
resultsThere was a significant dependency between cerebral and cerebellar language activation, with moderate negative correlation (Pearson r = -0.69). Crossed cerebrocerebellar language activation was present in both healthy participants and patients, irrespective of handedness or typical or atypical language representation. There were no discordant findings between fMRI and electrocortical stimulation.
conclusionsLanguage lateralization in the cerebellum can be considered an additional diagnostic feature to determine language dominance in patients with brain tumor. This is particularly useful in cases of uncertainty, such as the interference of a brain tumor with cerebral language activation on fMRI and atypical language representation.
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