ArticleGenome biology and evolution2014
Conserved and divergent patterns of DNA methylation in higher vertebrates.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Whole-Genome Methylation Analysis of Female, Male, and Neomale Northern Pike (Animals : an open access journal from MDPI · 2025Article
- Insights intoBiomolecules · 2025Article
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Sequencing Bait: Nuclear and Mitogenome Assembly of an Abundant Coastal Tropical and Subtropical Fish, Atherinomorus stipes.Genome biology and evolution · 2022Article
- Dnmt1a is essential for gene body methylation and the regulation of the zygotic genome in a wasp.PLoS genetics · 2022Article
- Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2021Article
- Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus).American journal of primatology · 2020Article
- The round goby genome provides insights into mechanisms that may facilitate biological invasions.BMC biology · 2020Article
- Hybrid Genome Assembly of a Neotropical Mutualistic Ant.Genome biology and evolution · 2019Article
- Article
- Changes in DNA methylation during epigenetic-associated sex reversal under low temperature in Takifugu rubripes.PloS one · 2019Article
- Pattern of DNA Methylation in Daphnia: Evolutionary Perspective.Genome biology and evolution · 2018Article
- Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for COScientific reports · 2018Article
- Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans.Mechanisms of ageing and development · 2017Article
- MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination.Epigenetics & chromatin · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation in the genome plays a fundamental role in the regulation of gene expression and is widespread in the genome of eukaryotic species. For example, in higher vertebrates, there is a "global" methylation pattern involving complete methylation of CpG sites genome-wide, except in promoter regions that are typically enriched for CpG dinucleotides, or so called "CpG islands." Here, we comprehensively examined and compared the distribution of CpG sites within ten model eukaryotic species and linked the observed patterns to the role of DNA methylation in controlling gene transcription. The analysis revealed two distinct but conserved methylation patterns for gene promoters in human and mouse genomes, involving genes with distinct distributions of promoter CpGs and gene expression patterns. Comparative analysis with four other higher vertebrates revealed that the primary regulatory role of the DNA methylation system is highly conserved in higher vertebrates.
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