Evidence map›Paper›PMID 25355775›Full record

Observational studyJournal of dental research2015

Predicting severe pain after root canal therapy in the National Dental PBRN.

A S Law, D R Nixdorf, A M Aguirre, G J Reams, A J Tortomasi, B D Manne, D R Harris, National Dental PBRN Collaborative Group

2 registry-linked trialsOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01201681 completednot on this map

Peri-operative Pain and Root Canal Therapy

TypeobservationalSponsorDental Practice-Based Research NetworkRan2010 to 2011Enrolled500ConditionsPost-operative Tooth Pain, Root Canal Therapy
NCT04787731 phase4suspendednot on this mapstarted 2019, after this paper: background citation

Efficacy of Two Dental Local Anesthetics on the Oral Health-Related Quality of Life After Endodontic Treatment in the Symptomatic Mandibular Molars: A Double Blind Randomized Controlled Trial

TypeinterventionalSponsorNYU College of DentistryRan2019 to 2024Enrolled100ConditionsPain, Postoperative, Quality of LifeArmsBupivacaine Local Anesthetic
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

A S LawPrivate Practice, The Dental Specialists, Lake Elmo, MN Division of Endodontics, School of Dentistry, University of Minnesota, Minneapolis, MN.
D R NixdorfDivision of TMD and Orofacial Pain, School of Dentistry, University of Minnesota, Minneapolis, MN Department of Neurology, Medical School, University of Minnesota, Minneapolis, MN HealthPartners Institute for Education and Research, Bloomington, MN nixdorf@umn.edu.
A M AguirrePrivate Practice, Endodontic Associates, Coon Rapids, MN.
G J ReamsPDA Permanente Dental Associates, Tigard, OR.
A J TortomasiPrivate Practice, Sumiton Dental, Sumiton, AL.
B D MannePrivate Practice, Ormond Beach, FL.
D R HarrisWestat, Rockville, MD.
National Dental PBRN Collaborative Group
University of Minnesota · USAmerican Association of Endodontists · USPeninsula Research · USSumitomo Dainippon Pharma (United States) · USWestat (United States) · US

Funding

The National Dental PBRNU19DE022516 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILBERT, GREGG H · 2012 to 2018
$66.4M
Dental PBRN Network ChairU01DE016747 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILBERT, GREGG H · 2005 to 2011
$17.3M
Scholar Development Clinical Research (RMI)K12RR023247 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LUEPKER, RUSSELL V · 2005 to 2009
$13.5M
Dental Practice-Based Research Network Coordinating CtrU01DE016746 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FUNKHOUSER, ELLEN M · 2005 to 2011
$7.0M
NCRR NIH HHS K12 RR023247NCRR NIH HHS K12-RR023247NIDCR NIH HHS U01 DE016746NIDCR NIH HHS U01-DE016746NIDCR NIH HHS U01 DE016747NIDCR NIH HHS U01-DE016747NIDCR NIH HHS U19 DE022516NIDCR NIH HHS U19-DE022516
6 · The paper itself

Abstract

Some patients experience severe pain following root canal therapy (RCT) despite advancements in care. We sought to identify factors, which can be measured preoperatively, that predict this negative outcome so that future research may focus on preemptive steps to reduce postoperative pain intensity. Sixty-two practitioners (46 general dentists and 16 endodontists) who are members of the National Dental Practice-Based Research Network enrolled patients receiving RCT for this prospective observational study. Baseline data collected from patients and dentists were obtained before treatment. Severe postoperative pain was defined based on a rating of ≥7 on a scale from 0 (no pain) to 10 (pain as bad as can be) for the worst pain intensity experienced during the preceding week, and this was collected 1 wk after treatment. Multiple logistic regression analyses were used to develop and validate the model. A total of 708 patients were enrolled during a 6-m period. Pain intensity data were collected 1 wk postoperatively from 652 patients (92.1%), with 19.5% (n = 127) reporting severe pain. In multivariable modeling, baseline factors predicting severe postoperative pain included current pain intensity (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.07 to 1.25; P = 0.0003), number of days in the past week that the subject was kept from their usual activities due to pain (OR, 1.32; 95% CI, 1.13 to 1.55; P = 0.0005), pain made worse by stress (OR, 2.55; 95% CI, 1.22 to 5.35; P = 0.0130), and a diagnosis of symptomatic apical periodontitis (OR, 1.63; 95% CI, 1.01 to 2.64; P = 0.0452). Among the factors that did not contribute to predicting severe postoperative pain were the dentist's specialty training, the patient's age and sex, the type of tooth, the presence of swelling, or other pulpal and apical endodontic diagnoses. Factors measured preoperatively were found to predict severe postoperative pain following RCT. Practitioners could use this information to better inform patients about RCT outcomes and possibly use different treatment strategies to manage their patients (Clinicaltrials.gov NCT01201681).

Indexed as

Activities of Daily LivingCohort StudiesCommunity-Based Participatory ResearchDental Pulp NecrosisEducational StatusFemaleForecastingHumansIntraoperative CareMaleMiddle AgedPain MeasurementPeriapical AbscessPeriapical PeriodontitisPostoperative PainProspective Studiesclinical outcomesclinical studies/trialsendodonticsevidence-based dentistry/health carepatient outcomespredictors

Identifiers

PMID25355775
PMCPMC4336154
OpenAlexW2148557791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.