ArticleJournal of diabetes science and technology2014
Effects of hemoglobin variants on hemoglobin a1c values measured using a high-performance liquid chromatography method.
Article in Journal of diabetes science and technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Glycemic assessment in diabetic patients with secondary polycytheamia: limitations of HbA1c and the potential role of fructosamine-a prospective comparative study.Acta diabetologica · 2026Observational
- Association between hemoglobin glycation index and delirium after gastric surgery: Based upon the MIMIC-IV.Medicine · 2026Article
- Ensuring HbA1c Accuracy and Variant Detection in Hemoglobin G-Coushatta and Queens Using Variant Mode Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- The limitations and fallacies of relying on glycosylated hemoglobin for diagnosing and monitoring diabetes in Indian populations.The Lancet regional health. Southeast Asia · 2026Review
- Low Hemoglobin A1c (HbA1c) Revealing Hemolytic Anemia in a Growth Hormone-Treated Child: A Case Report.Cureus · 2025Article
- Evaluation of the Biolabo Turbidimetric Assay for Automated Determination of Haemoglobin A1c.Diagnostics (Basel, Switzerland) · 2025Article
- Haemoglobin types and variant interference with HbA1c and its association with uncontrolled HbA1c in type 2 diabetes mellitus.BMC research notes · 2024Article
- Clinical Risk Assessment and Comparison of Bias between Laboratory Methods for Estimation of HbA1c for Glycated Hemoglobin in Hyperglycemic Patients.Current diabetes reviews · 2024Article
- Article
- Vulgarin, a Sesquiterpene Lactone fromInternational journal of molecular sciences · 2022Article
- Fibrinogen function indexes are potential biomarkers for evaluating the occurrence and severity of diabetic foot.Diabetology & metabolic syndrome · 2022Article
- A Rare Hemoglobin Variant (β51Pro → His) Causing Misleading Measurements of Hemoglobin AJournal of the Endocrine Society · 2022Article
- A potent weighted risk model for evaluating the occurrence and severity of diabetic foot ulcers.Diabetology & metabolic syndrome · 2021Article
- HbA mutation causing false-normal HbA1c results determined by HPLC in a patient with type 2 diabetes mellitus: A case report.Experimental and therapeutic medicine · 2021Article
- CE-HPLC Derived P2 and P3-Peaks in Health and in Hb D-Punjab and HbE States.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Effect of olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Labile haemoglobin as a glycaemic biomarker for patient-specific monitoring of diabetes: mathematical modelling approach.Journal of the Royal Society, Interface · 2018Article
- Effects of hemoglobin variants HbJ Bangkok, HbE, HbG Taipei, and HbH on analysis of glycated hemoglobin via ion-exchange high-performance liquid chromatography.Journal of clinical laboratory analysis · 2018Article
- Heterozygote Hemoglobin G-Coushatta as the Cause of a Falsely Decreased Hemoglobin A1C in an Ion-exchange HPLC Method.Journal of medical biochemistry · 2017Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hemoglobin A1c (HbA1c) is routinely used to monitor long-term glycemic control and for diagnosing diabetes mellitus. However, hemoglobin (Hb) gene variants/modifications can affect the accuracy of some methods. The potential effect of Hb variants on HbA1c measurements was investigated using a high-performance liquid chromatography (HPLC) method compared with an immunoturbimetric assay. Fasting plasma glucose (FPG) and HbA1c levels were measured in 42 371 blood samples. Samples producing abnormal chromatograms were further analyzed to characterize any Hb variants. Fructosamine levels were determined in place of HbA1c levels when unstable Hb variants were identified. Abnormal HPLC chromatograms were obtained for 160 of 42 371 samples. In 26 samples HbS was identified and HbA1c results correlated with FPG. In the remaining 134 samples HbD, Hb Louisville, Hb Las Palmas, Hb N-Baltimore, or Hb Porto Alegre were identified and HbA1c did not correlate with FPG. These samples were retested using an immunoturbidimetric assay and the majority of results were accurate; only 3 (with the unstable Hb Louisville trait) gave aberrant HbA1c results. Hb variants can affect determination of HbA1c levels with some methods. Laboratories should be aware of Hb variants occurring locally and choose an appropriate HbA1c testing method.
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