ArticleBMC complementary and alternative medicine2014
Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Photoprotection and Antiaging Activity of Extracts from Honeybush (Pharmaceutics · 2023Article
- Review
- Article
- The effect ofFrontiers in physiology · 2023Article
- Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Molecules (Basel, Switzerland) · 2021Article
- Skin Hydration Effects of Scale-Up FermentedEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Article
- Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities ofBioMed research international · 2018Article
- Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells.International journal of molecular sciences · 2017Article
- Anti-Photoaging Effect of Jeju Putgyul (Unripe Citrus) Extracts on Human Dermal Fibroblasts and Ultraviolet B-induced Hairless Mouse Skin.International journal of molecular sciences · 2017Article
- Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.Molecules (Basel, Switzerland) · 2016Article
- Protective effect of fermented Cyclopia intermedia against UVB-induced damage in HaCaT human keratinocytes.BMC complementary and alternative medicine · 2016Article
- Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line.Mediators of inflammation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects. Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin.
methodsThe inhibitory effects of honeybush extract and fermented honeybush on wrinkle formation were determined by analyzing skin replicas, histologically examining epidermal thickness, and identifying damage to collagen fibers.
resultsHoneybush extract and fermented honeybush reduced the length and depth of skin winkles caused by UV irradiation and inhibited thickening of the epidermal layer, in addition to suppressing collagen tissue breakdown reactions, indicating its potential use as a skin wrinkle prevention agent.
conclusionsThis in vivo study demonstrates that honeybush produces significant anti-wrinkle effects and is therefore of interest in anti-aging skin care products.
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