Evidence map›Paper›PMID 25355511›Full record

ArticleNucleic acids research2015

The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease.

Mary Shimoyama, Jeff De Pons, G Thomas Hayman, Stanley J F Laulederkind, Weisong Liu, Rajni Nigam, Victoria Petri, Jennifer R Smith, Marek Tutaj, Shur-Jen Wang and 3 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Article
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  17. Genomic changes underlying repeated niche shifts in an adaptive radiation.Evolution; international journal of organic evolution · 2022
    Article
  18. Article
  19. Review
  20. Article

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mary ShimoyamaHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA shimoyama@mcw.edu.
Jeff De PonsHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
G Thomas HaymanHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Stanley J F LaulederkindHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Weisong LiuHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Rajni NigamHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Victoria PetriHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jennifer R SmithHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Marek TutajHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Shur-Jen WangHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Elizabeth WortheyHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Melinda DwinellHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Howard JacobHuman and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Funding

RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ANNE E. KWITEK · 1999 to 2026
$50.0M
NHLBI NIH HHS HL64541NHLBI NIH HHS R01 HL064541
6 · The paper itself

Abstract

The Rat Genome Database (RGD, http://rgd.mcw.edu) provides the most comprehensive data repository and informatics platform related to the laboratory rat, one of the most important model organisms for disease studies. RGD maintains and updates datasets for genomic elements such as genes, transcripts and increasingly in recent years, sequence variations, as well as map positions for multiple assemblies and sequence information. Functional annotations for genomic elements are curated from published literature, submitted by researchers and integrated from other public resources. Complementing the genomic data catalogs are those associated with phenotypes and disease, including strains, QTL and experimental phenotype measurements across hundreds of strains. Data are submitted by researchers, acquired through bulk data pipelines or curated from published literature. Innovative software tools provide users with an integrated platform to query, mine, display and analyze valuable genomic and phenomic datasets for discovery and enhancement of their own research. This update highlights recent developments that reflect an increasing focus on: (i) genomic variation, (ii) phenotypes and diseases, (iii) data related to the environment and experimental conditions and (iv) datasets and software tools that allow the user to explore and analyze the interactions among these and their impact on disease.

Indexed as

Databases, GeneticGenetic VariationGenomicsPhenotypeAnimalsDiseaseEnvironmentGenomeInternetMolecular Sequence AnnotationRats

Identifiers

PMID25355511
PMCPMC4383884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.