ArticleJournal of nephrology2015
High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a.
Article in Journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Risk Factors of Disease Progression in IgA Nephropathy: A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2026Pooled it
- Hyperuricemia aggravates the progression of IgA nephropathy.International urology and nephrology · 2022Pooled it
- Effects of febuxostat on delaying chronic kidney disease progression: a randomized trial in China.International urology and nephrology · 2023Trial
- Article
- Crescents proportions above 10% are associated with unfavorable kidney outcomes in IgA nephropathy patients with partial crescent formation.Renal failure · 2023Article
- [Retrospective Analysis of the Effect of Uric Acid on the Prognosis of Immunoglobulin A Nephropathy With Stage 3-4 Chronic Kidney Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Hyperuricemia is associated with the progression of IgA nephropathy in children.Pediatric research · 2023Article
- Established the first clinical prediction model regarding the risk of hyperuricemia in adult IgA nephropathy.International urology and nephrology · 2023Article
- Hypocitraturia is present when renal function is impaired in diverse nephropathies and is not related with serum bicarbonate levels.International urology and nephrology · 2022Article
- An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2022Review
- Uric Acid and Impairment of Renal Function in Non-diabetic Hypertensive Patients.Frontiers in medicine · 2021Article
- Long-term renal survival and undetected risk factors of IgA nephropathy in Chinese children-a retrospective 1243 cases analysis from single centre experience.Journal of nephrology · 2020Article
- Sex Differences in Time-Series Changes in Pseudo-Journal of personalized medicine · 2020Article
- Monitoring Immune Responses in IgA Nephropathy: Biomarkers to Guide Management.Frontiers in immunology · 2020Review
- Article
- Clinical and histological features and therapeutic strategies for IgA nephropathy.Clinical and experimental nephrology · 2019Review
- Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis.Journal of atherosclerosis and thrombosis · 2017Article
- Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney.Journal of molecular histology · 2017Article
- Risk factors of progressive IgA nephropathy which progress to end stage renal disease within ten years: a case-control study.BMC nephrology · 2017Article
- Long-term outcome of IgA nephropathy with minimal change disease: a comparison between patients with and without minimal change disease.Journal of nephrology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh uric acid level is a known risk factor for deterioration of renal function in chronic kidney disease (CKD), but its influence on the progression of IgA nephropathy (IgAN) remains unclear.
methodsAdult IgAN patients (n = 611) were classified according to CKD stage. Renal survival rates and clinical and histological findings were compared between patients with high (H-UA) and normal (N-UA) uric acid levels in different CKD stages.
resultsThe proportion of patients with H-UA increased significantly with increasing CKD stage (stage G1, 12.3%; stage G2, 19.0%; stage G3a, 43.7%; stage G3b-4, 69.0%; P < 0.001). The 30-year renal survival rate was similar in patients with H-UA and N-UA in CKD stages G1, G2, and G3b-4, but was significantly lower in patients with H-UA than with N-UA in CKD stage G3a (24.7 vs. 51.9%; P = 0.0205). The clinical findings were similar in patients with H-UA and N-UA, but the interval from onset to biopsy differed between groups. The proportion of patients with global sclerosis was significantly higher in patients with H-UA than with N-UA in CKD stage G3a (33.3 vs. 11.4%; P = 0.0005), but the Oxford classifications were similar between groups. Multivariate Cox regression analysis identified H-UA (HR 1.36, 95% CI 1.07-1.72, P = 0.011) and a large amount of proteinuria (HR 1.38, 95% CI 1.09-1.74, P = 0.0084) as independent predictors of end-stage renal disease.
conclusionsH-UA induced global glomerular sclerosis and accelerated the progression of IgAN in CKD stage G3a.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.