ArticleScientific reports2014
Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026Article
- Ferroptosis spreads to neighboring cells via plasma membrane contacts.Nature communications · 2025Article
- A modular analysis of bile canalicular function and its implications for cholestasis.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1.JHEP reports : innovation in hepatology · 2023Article
- Hippo signalling in the liver: role in development, regeneration and disease.Nature reviews. Gastroenterology & hepatology · 2022Review
- Bile Duct-on-a-Chip.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A Bile Duct-on-a-Chip With Organ-Level Functions.Hepatology (Baltimore, Md.) · 2020Article
- Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation.Biomolecules · 2019Article
- Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology.Gene expression · 2019Review
- Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms.Clinical and translational medicine · 2018Review
- Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.Journal of hepatology · 2018Article
- Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer.International journal of molecular sciences · 2018Review
- Cell Junctions in Hippo Signaling.Cold Spring Harbor perspectives in biology · 2018Review
- C21 steroid-enriched fraction refined fromOncotarget · 2017Article
- Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis.Gastroenterology · 2017Review
- Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.Scientific reports · 2016Article
- Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.Nature communications · 2016Article
- YAP/TAZ at the Roots of Cancer.Cancer cell · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss of α-catenin, a well-established adhesion component, dramatically disrupts liver regeneration. Using a partial hepatectomy model, we show that regenerated livers from α-catenin knockdown mice are grossly larger than control regenerated livers, with an increase in cell size and proliferation. This increased proliferation correlated with increased YAP activation, implicating α-catenin in the Hippo/YAP pathway. Additionally, α-catenin knockdown mice exhibited a phenotype reminiscent of clinical cholestasis, with drastically altered bile canaliculi, elevated levels of bile components and signs of jaundice and inflammation. The disrupted regenerative capacity is a result of actin cytoskeletal disorganisation, leading to a loss of apical microvilli, dilated lumens in the bile canaliculi, and leaky tight junctions. This study illuminates a novel, essential role for α-catenin in liver regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.