ArticleJournal of molecular neuroscience : MN2015
Accumulation of cytoplasmic glucocorticoid receptor is related to elevation of FKBP5 in lymphocytes of depressed patients.
Article in Journal of molecular neuroscience : MN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Exploring the role of glucocorticoid receptors and co-chaperones in Pemphigus foliaceus stratification.Archives of dermatological research · 2025Article
- Identification of immune and major depressive disorder-related diagnostic markers for early nonalcoholic fatty liver disease by WGCNA and machine learning.Frontiers in bioinformatics · 2025Article
- Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder.World journal of psychiatry · 2021Review
- Stress modulates Ahi1-dependent nuclear localization of ten-eleven translocation protein 2.Human molecular genetics · 2021Article
- FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism.Brain, behavior, & immunity - health · 2020Article
- Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice.Alcoholism, clinical and experimental research · 2020Article
- Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.Brain and behavior · 2020Article
- The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder.The Journal of clinical investigation · 2020Article
- Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling.Psychoneuroendocrinology · 2018Article
- The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.International journal of molecular sciences · 2017Review
- Impaired Spinal Glucocorticoid Receptor Signaling Contributes to the Attenuating Effect of Depression on Mechanical Allodynia and Thermal Hyperalgesia in Rats with Neuropathic Pain.Frontiers in cellular neuroscience · 2017Article
- A focused Real Time PCR strategy to determine GILZ expression in mouse tissues.Results in immunology · 2015Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
We have previously shown that patients with the major depressive disorder (MDD) exhibited elevated phosphorylation of the lymphocyte glucocorticoid receptor (GR) at serine 226 (S226). Here, we further analyse potential alterations of GR signalization in lymphocytes of MDD patients, i.e. the cytoplasmic/nuclear distribution of GR, levels of FK506-binding protein 5 (FKBP5) and glucocorticoid-induced leucine zipper (GILZ). The FKBP5 acts as an important regulator of GR activation, by decreasing ligand binding and impeding translocation of the receptor to the nucleus, while GILZ mediates glucocorticoid anti-inflammatory effects. Our result showed that the depressed patients had significantly higher GR levels in the cytoplasm compared to controls, which was accompanied by higher FKBP5 levels. Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the presence of MDD itself or phosphorylation of nuclear GR at S226. There were no differences in the levels of GILZ isoforms. Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
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