ArticleAddiction (Abingdon, England)2015
Relative risk of injury from acute alcohol consumption: modeling the dose-response relationship in emergency department data from 18 countries.
Article in Addiction (Abingdon, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies.Addiction (Abingdon, England) · 2026Pooled it
- A meta-analysis of acute use of alcohol and the risk of suicide attempt.Psychological medicine · 2017Pooled it
- Protective behavioral strategies predict alcohol-related problems among injured patients following a brief intervention.Drug and alcohol dependence · 2019Trial
- Risk factors for alcohol-related injury experienced within a year: results of a nationwide large-scale internet survey.Addictive behaviors reports · 2026Article
- Role of socioeconomic status in modifying the relationship between alcohol use and injury events: evidence from the UK Biobank.Journal of epidemiology and community health · 2026Article
- Global burden and trend of substance use disorders, self-harm, and interpersonal violence from 1990 to 2021, with projection to 2040.BMC public health · 2025Article
- Do socioeconomic status, race and ethnicity modify the relationship between alcohol use and unintentional injury mortality?Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2025Article
- The impact of COVID-19-related national lockdowns on alcohol-related traffic collisions, injuries, and fatalities in Lithuania.Alcohol, clinical & experimental research · 2024Article
- Alcohol-Intoxicated Patients With Blunt Trauma and Head Injuries Have Better Outcomes Than Sober Patients.Cureus · 2024Article
- Alcohol and Substance Use Among the Working Age Population: A Nationwide Study of Fall-Related Emergency Department Visits.Journal of studies on alcohol and drugs · 2024Article
- National and regional prevalence of interpersonal violence from others' alcohol use: a systematic review and modelling study.The Lancet regional health. Europe · 2024Article
- Emergency Department Visits for Alcohol-Associated Falls Among Older Adults in the United States, 2011 to 2020.Annals of emergency medicine · 2023Article
- Role of alcohol in urgent ambulance contacts in 15-24-year-olds in Copenhagen: a descriptive population-based study.BMJ public health · 2023Article
- Associations between alcohol intake and hospital contacts due to alcohol and unintentional injuries in 71,025 Danish adolescents - a prospective cohort study.EClinicalMedicine · 2023Article
- Association between usual alcohol consumption and risk of falls in middle-aged and older Chinese adults.BMC geriatrics · 2022Article
- Alcohol consumption and related disorders in Iran: Results from the National Surveillance of Non-Communicable Diseases' Survey (STEPs) 2016.PLOS global public health · 2022Article
- Road traffic injury risk from alcohol and cannabis use among emergency department patients in Argentina.Revista panamericana de salud publica = Pan American journal of public health · 2022Article
- Trends and disparities in American Indian/Alaska Native unintentional injury mortality from 1999 to 2016.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2021Article
- Quantifying risk of injury from usual alcohol consumption: An instrumental variable analysis.Alcoholism, clinical and experimental research · 2021Article
- Alcohol and the Risk of Injury.Nutrients · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
aimsTo update and extend analysis of the dose-response relationship of injury and drinking by demographic and injury subgroups and country-level drinking pattern, and examine the validity and efficiency of the fractional polynomial approach to modeling this relationship.
designPair-matched case-cross-over analysis of drinking prior to injury, using categorical step-function and fractional polynomial analysis.
settingThirty-seven emergency departments (EDs) across 18 countries.
participantsA total of 13 119 injured drinkers arriving at the ED within 6 hours of the event. MEASUREMENTS: The dose-response relationship was analyzed by gender, age, cause of injury (traffic, violence, fall, other) and country detrimental drinking pattern (DDP).
findingsEstimated risks were similar between the two analytical methods, with injury risk doubling at one drink [odds ratio (OR) = 2.3-2.7] and peaking at about 30 drinks. Although risk was similar for males and females up to three drinks (OR = 4.6), it appeared to increase more rapidly for females and was significantly higher starting from 20 drinks [female OR = 28.6; confidence interval (CI) = 16.8, 48.9; male OR = 12.8; CI = 10.1, 16.3]. No significant differences were found across age groups. Risk was significantly higher for violence-related injury than for other causes across the volume range. Risk was also higher at all volumes for DDP-3 compared with DDP-2 countries.
conclusionsThere is an increasing risk relationship between alcohol and injury but risk is not uniform across gender, cause of injury or country drinking pattern. The fractional polynomial approach is a valid and efficient approach for modeling the alcohol injury risk relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.