ArticleAmerican journal of medical genetics. Part A2015
Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
Article in American journal of medical genetics. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- Trial
- Disordered pancreatic and gastrointestinal hormone responses to nutrient stimulation in Zambian children with severe acute malnutrition.Experimental physiology · 2026Article
- Case report: Long-term efficacy and safety of semaglutide in the treatment of syndromic obesity in Prader Willi syndrome - case series and literature review.Frontiers in endocrinology · 2024Review
- Management of Hyperphagia and Obesity in Prader-Willi Syndrome.Ewha medical journal · 2023Review
- Malignancies in Prader-Willi Syndrome: Results From a Large International Cohort and Literature Review.The Journal of clinical endocrinology and metabolism · 2023Review
- Hormonal Imbalances in Prader-Willi and Schaaf-Yang Syndromes Imply the Evolution of Specific Regulation of Hypothalamic Neuroendocrine Function in Mammals.International journal of molecular sciences · 2023Review
- Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader-Willi syndrome.Obesity science & practice · 2023Article
- Hyperphagia in Prader-Willi syndrome with obesity: From development to pharmacological treatment.Intractable & rare diseases research · 2023Review
- Prader-Willi syndrome, deletion subtypes, and magnesium: Potential impact on clinical findings.American journal of medical genetics. Part A · 2022Article
- Do patients with Prader-Willi syndrome have favorable glucose metabolism?Orphanet journal of rare diseases · 2022Review
- Serum alpha-melanocyte-stimulating hormone (a-MSH), brain-derived neurotrophic factor (BDNF), and agouti-related protein (AGRP) levels in children with Prader-Willi or Bardet-Biedl syndromes.Journal of endocrinological investigation · 2022Article
- Prader-Willi syndrome: an update on obesity and endocrine problems.Annals of pediatric endocrinology & metabolism · 2021Article
- Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?Journal of clinical medicine · 2021Article
- Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches.Journal of endocrinological investigation · 2021Review
- Is ghrelin a biomarker of early-onset scoliosis in children with Prader-Willi syndrome?Orphanet journal of rare diseases · 2021Article
- The Function of Gastrointestinal Hormones in Obesity-Implications for the Regulation of Energy Intake.Nutrients · 2021Review
- Appetite- and weight-inducing and -inhibiting neuroendocrine factors in Prader-Willi syndrome, Bardet-Biedl syndrome and craniopharyngioma versus anorexia nervosa.Endocrine connections · 2021Review
- "A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes".Molecular metabolism · 2021Review
- An overview of ghrelinExpert opinion on therapeutic patents · 2020Review
- Successful rapid weight reduction and the use of liraglutide for morbid obesity in adolescent Prader-Willi syndrome.Annals of pediatric endocrinology & metabolism · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Circulating total ghrelin levels are elevated in older children and adults with Prader-Willi syndrome (PWS). However, the presence or absence of hyperghrelinemia in young children with PWS remains controversial. We hypothesized that a more robust way to analyze appetite-regulating hormones in PWS would be by nutritional phases rather than age alone. Our objectives were to compare total serum ghrelin levels in children with PWS by nutritional phase as well as to compare total ghrelin levels in PWS (5 weeks to 21 years of age) to normal weight controls and individuals with early-onset morbid obesity (EMO) without PWS. Fasting serum total ghrelin levels were measured in 60 subjects with PWS, 39 subjects with EMO of unknown etiology, and in 95 normal non-obese sibling controls of PWS or EMO subjects (SibC) in this 12 year longitudinal study. Within PWS, total ghrelin levels were significantly (P < 0.001) higher in earlier nutritional phases: phase 1a (7,906 ± 5,887); 1b (5,057 ± 2,624); 2a (2,905 ± 1,521); 2b (2,615 ± 1,370) and 3 (2,423 ± 1,350). Young infants with PWS also had significantly (P = 0.009) higher total ghrelin levels than did the sibling controls. Nutritional phase is an important independent prognostic factor of total ghrelin levels in individuals with PWS. Circulating ghrelin levels are elevated in young children with PWS long before the onset of hyperphagia, especially during the early phase of poor appetite and feeding. Therefore, it seems unlikely that high ghrelin levels are directly responsible for the switch to the hyperphagic nutritional phases in PWS.
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