ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Relative valuation of pain in human orbitofrontal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03294148 (Mind-body Treatments for Chronic Back Pain), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mind-body Treatments for Chronic Back Pain
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Economic value in the Brain: A meta-analysis of willingness-to-pay using the Becker-DeGroot-Marschak auction.PloS one · 2023Pooled it
- Central encoding of the strength of intranasal chemosensory trigeminal stimuli in a human experimental pain setting.Human brain mapping · 2020Trial
- Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.PloS one · 2019Trial
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.bioRxiv : the preprint server for biology · 2026Article
- BOLD repetition enhancement in the orbitofrontal cortex during complex visuospatial processing in migraine without aura: a shift in periaqueductal gray - cortical coupling?The journal of headache and pain · 2026Article
- Perspectives on Pain: A Narrative Review of Pain Beliefs, Coping, and Clinical Implications.Journal of pain research · 2026Review
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.Frontiers in neuroscience · 2026Article
- No facilitatory effects of transcranial random noise stimulation on motion processing: A registered report.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Neuromodulation of Dopamine D2 Receptors Alters Orbitofrontal Neuronal Activity and Reduces Risk-Prone Behavior in Male Rats with Inflammatory Pain.Molecular neurobiology · 2025Article
- Central effects of short-term spinal cord stimulation in postherpetic neuralgia: a longitudinal fMRI and DTI study.Frontiers in neuroscience · 2025Article
- Chronic spinal cord injury is associated with morphometric brain changes in functional networks beyond the sensorimotor system.Frontiers in neurology · 2025Article
- Electrophysiological population dynamics reveal context dependencies during decision making in human frontal cortex.Nature communications · 2023Article
- Human ventromedial prefrontal cortex lesions enhance the effect of expectations on pain perception.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Alteration of static and dynamic intrinsic brain activity induced by short-term spinal cord stimulation in postherpetic neuralgia patients.Frontiers in neuroscience · 2023Article
- The neural signature of the decision value of future pain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers.IBRO reports · 2019Article
- Effects of Positive and Negative Expectations on Human Pain Perception Engage Separate But Interrelated and Dependently Regulated Cerebral Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Opioid-Independent and Opioid-Mediated Modes of Pain Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Pain Neuroimaging in Humans: A Primer for Beginners and Non-Imagers.The journal of pain · 2018Review
- Modeling Pain Using fMRI: From Regions to Biomarkers.Neuroscience bulletin · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The valuation of health-related states, including pain, is a critical issue in clinical practice, health economics, and pain neuroscience. Surprisingly the monetary value people associate with pain is highly context-dependent, with participants willing to pay more to avoid medium-level pain when presented in a context of low-intensity, rather than high-intensity, pain. Here, we ask whether context impacts upon the neural representation of pain itself, or alternatively the transformation of pain into valuation-driven behavior. While undergoing fMRI, human participants declared how much money they would be willing to pay to avoid repeated instances of painful cutaneous electrical stimuli delivered to the foot. We also implemented a contextual manipulation that involved presenting medium-level painful stimuli in blocks with either low- or high-level stimuli. We found no evidence of context-dependent activity within a conventional "pain matrix," where pain-evoked activity reflected absolute stimulus intensity. By contrast, in right lateral orbitofrontal cortex, a strong contextual dependency was evident, and here activity tracked the contextual rank of the pain. The findings are in keeping with an architecture where an absolute pain valuation system and a rank-dependent system interact to influence willing to pay to avoid pain, with context impacting value-based behavior high in a processing hierarchy. This segregated processing hints that distinct neural representations reflect sensory aspects of pain and components that are less directly nociceptive whose integration also guides pain-related actions. A dominance of the latter might account for puzzling phenomena seen in somatization disorders where perceived pain is a dominant driver of behavior.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.