Evidence map›Paper›PMID 25355045›Full record

ArticleBMC cancer2014

Descriptive Epidemiology in Mexican children with cancer under an open national public health insurance program.

Roberto Rivera-Luna, Jaime Shalkow-Klincovstein, Liliana Velasco-Hidalgo, Rocio Cárdenas-Cardós, Marta Zapata-Tarrés, Alberto Olaya-Vargas, Marco R Aguilar-Ortiz, Eduardo Altamirano-Alvarez, Cecilia Correa-Gonzalez, Fernando Sánchez-Zubieta and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05326984 (Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05326984 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia

TypeinterventionalSponsorHospital General de MexicoRan2021 to 2023Enrolled20ConditionsAcute Lymphoblastic LeukemiaArmsMetformin
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Clinical Outcomes of Pediatric Acute Lymphoblastic Leukemia in the Bajio Region of Mexico: A Retrospective Cohort Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Roberto Rivera-LunaHead of the Division of Pediatric Hem/Oncology, National Institute of Pediatrics (NIP), Coordinator for the Technical Committee of the National Council for the Prevention and Treatment of Childhood Cancer, Mexico City, Mexico. riveraluna@terra.com.mx.
Jaime Shalkow-Klincovstein
Liliana Velasco-Hidalgo
Rocio Cárdenas-Cardós
Marta Zapata-Tarrés
Alberto Olaya-Vargas
Marco R Aguilar-Ortiz
Eduardo Altamirano-Alvarez
Cecilia Correa-Gonzalez
Fernando Sánchez-Zubieta
Francisco Pantoja-Guillen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAll the children registered at the National Council for the Prevention and Treatment of Childhood Cancer were analyzed. The rationale for this Federal Government Council is to financially support the treatment of all children registered into this system. All patients are within a network of 55 public certified hospitals nationwide.

methodsIn the current study, data from 2007 to 2012 are presented for all patients (0-18 years) with a pathological diagnosis of leukemia, lymphoma and solid tumors. The parameters analyzed were prevalence, incidence, mortality, and abandonment rate.

resultsA diagnosis of cancer was documented in 14,178 children. The incidence was of 156.9/million/year (2012). The median age was 4.9. The most common childhood cancer is leukemia, which occurs in 49.8% of patients (2007-2012); and has an incidence rate of 78.1/million/year (2012). The national mortality rate was 5.3/100,000 in 2012, however in the group between 15 to 18 years it reaches a level of 8.6.

conclusionsThe study demonstrates that there is a high incidence of childhood cancer in Mexico. In particular, the results reveal an elevated incidence and prevalence of leukemia especially from 0 to 4 years. Only 4.7% of these patients abandoned treatment. The clinical outcome for all of the children studied improved since the establishment of this national program.

Indexed as

Insurance, HealthPublic Health SurveillanceAdolescentChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleMexicoNeoplasmsPrevalenceRegistries

Identifiers

PMID25355045
PMCPMC4228174

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.