Evidence map›Paper›PMID 25355032›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma.

Krzysztof Szyfter, Malgorzata Wierzbicka, Jennifer L Hunt, Alessandra Rinaldo, Juan P Rodrigo, Robert P Takes, Alfio Ferlito

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Krzysztof SzyfterInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Malgorzata WierzbickaDepartment of Otolaryngology and Laryngeal Oncology, K. Marcinkowski University of Medical Sciences, Poznan, Poland.
Jennifer L HuntDepartment of Pathology and Laboratory Services, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Alessandra RinaldoUniversity of Udine School of Medicine, Udine, Italy.
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Robert P TakesDepartment of Otolaryngology Head and Neck Surgery, Radboud University Medicine Center, Nijmegen, The Netherlands.
Alfio FerlitoUniversity of Udine School of Medicine, Udine, Italy. a.ferlito@uniud.it.
University of Udine · ITHospital Universitario Central de Asturias · ESInstitute of Human Genetics · PLPoznan University of Medical Sciences · PLRadboud University Nijmegen · NLUniversity of Arkansas for Medical Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knowledge of the biology of head and neck squamous cell carcinoma (HNSCC) has had relatively little impact on the improvement in oncologic outcome up to date. However, the identification of oncogenes and tumor suppressor genes (TSGs) involved in cancer progression contributes to the understanding of the molecular pathways involved in oncogenesis and could contribute to individual risk assessment and provide tools for improvement of treatment and targets for therapy based on the alterations in these pathways. The aim of this article is to review the chromosomal aberrations commonly found in HNSCC, to identify the genes in these chromosomal regions suggested to act as (candidate) oncogenes or TSGs, and to discuss the molecular mechanisms modulating their expression.

Indexed as

Chromosome AberrationsCarcinoma, Squamous CellGenes, Tumor SuppressorHead and Neck NeoplasmsHumansOncogenesChromosome alterationsHead and neck carcinomaMarkers of progressionOncogenesTumor suppressor genes

Identifiers

PMID25355032
OpenAlexW2055975111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.