ArticleJournal of human hypertension2015
Sex-specific relations between fasting insulin, insulin resistance and incident hypertension: 8.9 years follow-up in a Middle-Eastern population.
Article in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Pooled it
- The association between triglyceride glucose-body mass index and all-cause and cardiovascular mortality in diabetes patients: a retrospective study from NHANES database.Scientific reports · 2024Article
- Association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute coronary syndrome: results from the Improving Care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome project.Cardiovascular diabetology · 2024Observational
- The association of ideal cardiovascular health metrics and incident hypertension among an urban population of Iran: a decade follow-up in Tehran Lipid and Glucose Study.Journal of human hypertension · 2024Article
- Sex differences in risk factors for coronary heart disease events: a prospective cohort study in Iran.Scientific reports · 2023Article
- Additive interactions between obesity and insulin resistance on hypertension in a Chinese rural population.BMC public health · 2023Article
- Association of glycemic control with hypertension in patients with diabetes: a population-based longitudinal study.BMC cardiovascular disorders · 2023Article
- The relationship and interaction between triglyceride glucose index and obesity in the risk of prehypertension population: a cross-sectional study from a survey in Anhui, Eastern China.BMC cardiovascular disorders · 2023Article
- Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women.Cardiovascular diabetology · 2023Article
- Association of three insulin resistance indices with hypertension and body weight among Uyghur adults in rural areas of Xinjiang, China.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Triglyceride-to-glucose index to detect a non-dipping circadian pattern in newly diagnosed hypertensive patients.Journal of cardiovascular and thoracic research · 2022Article
- Lifestyle interventions for the prevention and treatment of hypertension.Nature reviews. Cardiology · 2021Review
- Triglyceride-glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort.Cardiovascular diabetology · 2021Observational
- Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.The Canadian journal of cardiology · 2020Review
- Sex-Specific Incidence Rates and Risk Factors for Hypertension During 13 Years of Follow-up: The Tehran Lipid and Glucose Study.Global heart · 2020Article
- Sex specific impact of different obesity phenotypes on the risk of incident hypertension: Tehran lipid and glucose study.Nutrition & metabolism · 2019Article
- Impact of 3-year changes in fasting insulin and insulin resistance indices on incident hypertension: Tehran lipid and glucose study.Nutrition & metabolism · 2019Article
- Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease.Journal of the American Heart Association · 2016Observational
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate whether fasting serum insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) and insulin-to-glucose ratio (IGR) were associated with incident hypertension. In a prospective study, 4093 Iranian participants (1725 men and 2368 women) without hypertension and known diabetes at baseline (1999-2001) were followed for a median of 8.9 years. Regular follow-up examinations were performed at 3-year intervals. Multivariate Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident hypertension adjusting for sex, and in sex-stratified models. During the study, 896 incident cases of hypertension (432 men and 464 women) were identified (total incident rate: 27.5 per 1000 person-years). In the multivariable models, serum insulin level, HOMA-IR and IGR were positively associated with hypertension incidence, adjusting for sex. In the sex-stratified analyses, after adjusting for potential confounders, women in the highest quartile of insulin, HOMA-IR and IG had a significantly higher incidence of hypertension, compared with those in the lowest quartile (HR: 1.7 (95% CI 1.26-2.30); HR: 1.80 (95% CI 1.31-2.40) and HR: 1.67 (95% CI 1.26-2.22), respectively); among men, these relations were also significant, until including waist circumference and body mass index in the models (HR: 1.17 (95% CI 0.85-1.62), HR: 1.25 (95% CI 0.91-1.73) and HR: 1.06 (95% CI 0.77-1.45), respectively). Higher fasting serum insulin levels, HOMA-IR and IGR were associated with incident hypertension among women, whereas these associations were not significant after adjusting for obesity measures in men.
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