ArticleGlycoconjugate journal1989
Muramyl dipeptide bound to poly-L-lysine substituted with mannose and gluconoyl residues as macrophage activators.
Article in Glycoconjugate journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 72 citations in OpenAlex.
- Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.Nature biotechnology · 2010Article
- Mannan-mediated gene delivery for cancer immunotherapy.Immunology · 2007Article
- Carrier-based strategies for targeting protein and peptide drugs to the lungs.The AAPS journal · 2005Review
- Intracellular rate-limiting steps of gene transfer using glycosylated polylysines in cystic fibrosis airway epithelial cells.Gene therapy · 2002Article
- The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells.Pharmaceutical research · 2002Article
- Gene therapy of cystic fibrosis: the glycofection approach.Glycoconjugate journal · 2001Review
- Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides.Nucleic acids research · 2000Article
- Sensitive, hydrosoluble, macromolecular fluorogenic substrates for human immunodeficiency virus 1 proteinase.The Biochemical journal · 1993Article
- Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells.Nucleic acids research · 1993Article
- Antileishmanial drug targeting through glycosylated polymers specifically internalized by macrophage membrane lectins.Antimicrobial agents and chemotherapy · 1992Article
- Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates.Nucleic acids research · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly-L-lysine modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP). The influence of the acylating agent on the targeting efficiency was investigated: a hydrosolubilizing group such as a gluconoyl moiety led to very efficient carrier conjugates, while an acetyl group did not. The effect of sugar and acyl content of the polymers was assessed using these compounds as inhibitors of red blood cell agglutination by Concanavalin A. The binding and specific endocytosis of poly-L-lysine substituted with several mannose derivatives and gluconoyl residues (GlcAx-, Man(y)-PLK) have been determined by a quantitative flow cytometry analysis. MDP bound to these conjugates was much more efficient in vitro than free MDP in macrophage cytostasis assays.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.