Evidence map›Paper›PMID 25354736›Full record

ArticleAIDS and behavior2015

Health literacy in HIV treatment: accurate understanding of key biological treatment principles is not required for good ART adherence.

M Barton Laws, Michael Danielewicz, Aadia Rana, Laura Kogelman, Ira B Wilson

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

M Barton LawsDepartment of Health Services, Policy and Practice, Brown University School of Public Health, G-S121-7, Providence, RI, 02912, USA, michael_barton_laws@brown.edu.
Michael Danielewicz
Aadia Rana
Laura Kogelman
Ira B Wilson
John Brown University · USBrown University · USMiriam Hospital · USTufts Medical Center · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Improving the diagnosis and treatment of medication adherence problems in HIVK24MH092242 · NIMH · BROWN UNIVERSITY · PI WILSON, IRA B · 2010 to 2014
$937k
Explanatory models of illness and decision heuristics in HIV careR21MH092781 · NIMH · BROWN UNIVERSITY · PI LAWS, MICHAEL BARTON · 2011 to 2012
$472k
NIAID NIH HHS P30 AI042853NIMH NIH HHS 1R21MH092781-01NIMH NIH HHS K24 MH092242NIMH NIH HHS R21 MH092781
6 · The paper itself

Abstract

Findings on the relationship between health literacy and outcomes in HIV have been inconsistent. Health literacy has previously been operationalized as general functional literacy, but has not included content knowledge about HIV disease and treatment. Semi-structured interviews with people living with HIV in 2 U.S. cities, including questions about the etiology, pathophysiology and treatment of HIV. We compared responses to biomedical conceptions. The 32 respondents were demographically diverse. Although most understood that HIV degrades the immune system, none could explain the nature of a virus, or the mechanism of antiretroviral (ARV) drug action. Fewer than half accurately reported that it is desirable to have a high CD4+ cell count and low viral load. A minority understood the concept of drug resistance. While most believed that strict adherence to ARV regimens was important to maintain health, three believed that periodic treatment interruption was beneficial, and three believed they should not take ARVs when they used alcohol or illicit drugs. Respondents generally had very limited, and often inaccurate biomedical understanding of HIV disease. Most reported good regimen adherence but did not have any mechanistic rationale for it. The failure to find a consistent relationship between health literacy and ARV adherence may be largely because most people simply follow their doctors' instructions, without the need for deep understanding.

Indexed as

Antiretroviral Therapy, Highly ActiveComprehensionDecision MakingDrug MonitoringHealth Knowledge, Attitudes, PracticeHealth LiteracyAdultCD4 Lymphocyte CountFemaleHIV InfectionsHumansMaleMiddle AgedUnited StatesViral LoadYoung Adult

Identifiers

PMID25354736
PMCPMC4765166
OpenAlexW2031683913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.