ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2014
Eradicating group A streptococcus bacteria and biofilms using functionalised multi-wall carbon nanotubes.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Antimicrobial Nanotubes: From Synthesis and Promising Antimicrobial Upshots to Unanticipated Toxicities, Strategies to Limit Them, and Regulatory Issues.Nanomaterials (Basel, Switzerland) · 2025Review
- Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models.The Journal of clinical investigation · 2023Article
- Recent advances in targeted antibacterial therapy basing on nanomaterials.Exploration (Beijing, China) · 2023Review
- Carbon nanotube/waterborne polyurethane nanocomposites with light-to-heat conversion properties.Turkish journal of chemistry · 2023Article
- An Overview of Antimicrobial Properties of Carbon Nanotubes-Based Nanocomposites.Advanced pharmaceutical bulletin · 2022Review
- Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.Pharmaceutics · 2021Review
- Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation.Bioactive materials · 2021Article
- Antimicrobial and anti-adhesive properties of carbon nanotube-based surfaces for medical applications: a systematic review.iScience · 2021Review
- Nanocomposite Sprayed Films with Photo-Thermal Properties for Remote Bacteria Eradication.Nanomaterials (Basel, Switzerland) · 2020Article
- CuS nanoparticles anchored to g-CRSC advances · 2020Article
- Phototherapy-based combination strategies for bacterial infection treatment.Theranostics · 2020Review
- Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms.Beilstein journal of nanotechnology · 2020Review
- Antibody-Functionalized MoSFrontiers in bioengineering and biotechnology · 2019Article
- Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms.Nature communications · 2018Article
- Carbon nanotubes as anti-bacterial agents.Cellular and molecular life sciences : CMLS · 2017Review
- Synergistic Photothermal and Antibiotic Killing of Biofilm-AssociatedACS infectious diseases · 2016Article
- A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this study was to demonstrate that multi-wall carbon nanotubes can be functionalised with antibodies to group A streptoccocus (GAS) for targeted photothermal ablation of planktonic and biofilm residing bacteria. MATERIALS AND
methodsAntibodies for GAS were covalently attached to carboxylated multi-wall carbon nanotubes and incubated with either planktonic or biofilm GAS. Bacterium was then exposed to 1.3 W/cm(2) of 800 nm light for 10-120 s, and then serially diluted onto agar plates from which the number of colony forming units was determined. Photothermal ablation of GAS on the surface of full thickness ex vivo porcine skin and histological sectioning were done to examine damage in adjacent tissue.
resultsApproximately 14% of the GAS antibody-functionalised nanotubes attached to the bacterium, and this amount was found to be capable of inducing photothermal ablation of GAS upon exposure to 1.3 W/cm(2) of 800 nm light. Cell viability was not decreased upon exposure to nanotubes or infrared light alone. Compared to carboxylated multi-wall carbon nanotubes, antibody-labelled nanotubes enhanced killing in both planktonic and biofilm GAS in conjunction with infrared light. Analysis of GAS photothermally ablated in direct contact with ex vivo porcine skin shows that heat sufficient for killing GAS remains localised and does not cause collateral damage in tissue adjacent to the treated area.
conclusionsThe results of this study support the premise that carbon nanotubes may be effectively utilised as highly localised photothermal agents with the potential for translation into the clinical treatment of bacterial infections of soft tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.